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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Blue light is phototoxic for B16F10 murine melanoma and bovine endothelial cell lines by direct cytocidal effect.
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Blue light is phototoxic for B16F10 murine melanoma and bovine endothelial cell lines by direct cytocidal effect.

机译：蓝光通过直接的杀细胞作用对B16F10鼠黑色素瘤和牛内皮细胞系具有光毒性。

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摘要

The large number of studies devoted to the effect of ultraviolet light on biological systems, contrasts with the lack of experimental data concerning the direct effects of visible light. It has been shown that blue light inhibited the growth of B16F10 melanoma cell lines and reduced the percentage of S phase cells. Yet these effects are poorly understood. MATERIALS AND METHODS: Two cell lines and irradiation with blue light were used. Cell mortality and a possible mechanism of action were investigated. RESULTS: Exposure of B16F10 melanoma and bovine endothelial cells to blue light (wavelength 450 nm, 10 J/cm(2) from a Waldman lamp) induced a rapid and large reduction in viability followed by the death of virtually all the irradiated cells within 24 h. These results led us to expose a patient with haemorrhagic cutaneous melanoma metastasis to blue light. Irradiation led to an immediate arrest of haemorrhage, an inhibition of tumour growth and extensive tumour necrosis 24h after irradiation. CONCLUSION: Exposure to blue light may offer new approaches to the treatment of superficial skin carcinomas in humans.
机译：大量致力于紫外线对生物系统影响的研究与缺乏有关可见光直接作用的实验数据形成了鲜明对比。已经显示，蓝光抑制了B16F10黑色素瘤细胞系的生长并降低了S期细胞的百分比。然而，这些影响知之甚少。材料与方法：使用两种细胞系并用蓝光照射。研究了细胞死亡率和可能的作用机制。结果：B16F10黑色素瘤和牛内皮细胞暴露于蓝光（波长为450 nm，来自Waldman灯的10 J / cm（2））导致活力迅速，大幅度下降，随后几乎所有24岁的受照射细胞死亡H。这些结果使我们将出血的皮肤黑色素瘤转移患者暴露在蓝色光下。辐照可导致出血立即停止，在辐照后24h抑制肿瘤生长和广泛的肿瘤坏死。结论：暴露于蓝光可能为治疗人类浅表皮肤癌提供新的方法。

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