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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Docetaxel is effective in the treatment of metastatic endometrial cancer.
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Docetaxel is effective in the treatment of metastatic endometrial cancer.

机译：多西他赛对转移性子宫内膜癌有效。

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BACKGROUND: Systemic treatment of endometrial carcinoma with distant metastases is currently performed, inter alia, with anthracyclines, platinum, paclitaxel, if osfamid or progestins. This is the first report presenting experience in treatment of metastatic endometrial carcinoma with docetaxel. CASE REPORT: A 69-year-old women with adenocarcinoma of the endometrium was treated with primary combined radiotherapy. Two years later disseminated bilateral pulmonary metastases were detected and the patient was submitted to chemotherapy with epirubicin. After three cycles of chemotherapy with epirubicin examinations revealed metastatic progression. Thus, chemotherapy was changed to docetaxel. RESULTS: After three cycles of chemotherapy with docetaxel examinations revealed remission of the described pulmonary metastases more than 50%. A further three cycles of chemotherapy with docetaxel lead to continuing shrinkage of the detectable metastases to less than 25% of the original size. Because of various side effects, like increasing fatigue and asthenia, uncomfortable acral paresthesia and allergic skin reactions, the patient refused to continue chemotherapy. CONCLUSION: We conclude that docetaxel may be an active agent in patients with metastatic endometrial cancer, but care should be taken to minimize side-effects.
机译：背景：子宫内膜癌具有远处转移的系统性治疗目前尤其是用蒽环类药物，铂，紫杉醇（如果使用奥斯法米定或孕激素）进行。这是第一份介绍多西他赛治疗转移性子宫内膜癌经验的报告。病例报告：一名69岁子宫内膜腺癌妇女接受了一次联合放疗。两年后，检测到弥漫性双侧肺转移，患者接受表柔比星化疗。经过三个周期的表柔比星化疗后显示转移进展。因此，化学疗法改为多西他赛。结果：经过三个周期的多西他赛化疗化疗后，发现所描述的肺转移缓解率超过50％。多西紫杉醇的另外三个化疗周期导致可检测到的转移灶持续缩小至原始大小的25％以下。由于各种副作用，例如增加疲劳和乏力，不舒服的肢端感觉异常和皮肤过敏反应，患者拒绝继续化疗。结论：我们得出结论，多西紫杉醇可能是转移性子宫内膜癌患者的一种活性药物，但应注意减少其副作用。

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