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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Expression of Fas ligand in newly diagnosed childhood acute lymphoblastic leukemia.
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Expression of Fas ligand in newly diagnosed childhood acute lymphoblastic leukemia.

机译:Fas配体在新诊断的儿童急性淋巴细胞白血病中的表达。

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摘要

Immunocytochemistry was used to analyze the expression of the Fas ligand (FasL) in sixty-four children with newly diagnosed acute lymphoblastic leukemia (ALL). FasL expression was detected in 55 of 64 children (86%). Children with newly diagnosed ALL and FasL expression exhibited longer relapse-free and overall survival times under chemotherapy than did patients who did not express the Fas ligand. These data suggest that Fas/FasL mediated signaling may play a general role in the cytotoxicity of anticancer drugs.
机译:免疫细胞化学被用来分析Fas配体(FasL)在64名新诊断为急性淋巴细胞白血病(ALL)的儿童中的表达。在64名儿童中有55名(86%)检测到FasL表达。与不表达Fas配体的患者相比,新诊断为ALL和FasL表达的儿童在化疗下表现出更长的无复发和总体生存时间。这些数据表明,Fas / FasL介导的信号传导可能在抗癌药物的细胞毒性中起一般作用。

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