Induction of apoptosis by a nonnucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitor.

Pilon AA; Lum JJ; Sanchez Dardon J; Phenix BN; Douglas R; Badley AD

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Induction of apoptosis by a nonnucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitor.

机译：非核苷类人免疫缺陷病毒1型逆转录酶抑制剂诱导的细胞凋亡。

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Inhibition of human immunodeficiency virus type 1 reverse transcriptase (RT) by both nucleoside and nonnucleoside RT inhibitors profoundly inhibits virus replication. Nucleoside RT inhibitors are known to be toxic, but there is little information regarding the toxicities of nonnucleoside RT inhibitors (NNRTI). We demonstrate that efavirenz (an NNRTI) induces caspase- and mitochondrion-dependent apoptosis of Jurkat T cells and human peripheral blood mononuclear cells. The clinical relevance of these observations is not yet clear.

机译：核苷和非核苷RT抑制剂对人免疫缺陷病毒1型逆转录酶（RT）的抑制作用均会深深地抑制病毒复制。已知核苷RT抑制剂具有毒性，但是关于非核苷RT抑制剂（NNRTI）毒性的信息很少。我们证明依法韦仑（NNRTI）诱导Jurkat T细胞和人类外周血单核细胞的caspase和线粒体依赖性凋亡。这些观察的临床相关性尚不清楚。

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《Antimicrobial agents and chemotherapy.》 |2002年第8期|共5页
作者
Pilon AA; Lum JJ; Sanchez Dardon J; Phenix BN; Douglas R; Badley AD;
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正文语种 eng
中图分类治疗学;
关键词
inhibitors; Apoptosis; HIV; Induction; Reverse Transcriptase Inhibitors; 脱噬作用; 逆转录酶抑制剂;

机译：inhibitors;Apoptosis;HIV;Induction;Reverse Transcriptase Inhibitors;脱噬作用;逆转录酶抑制剂;

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1. Induction of apoptosis by a nonnucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitor. [J] . Pilon AA, Lum JJ, Sanchez Dardon J, Antimicrobial agents and chemotherapy. . 2002,第8期

机译：非核苷类人免疫缺陷病毒1型逆转录酶抑制剂诱导的细胞凋亡。
2. In vitro selection of mutations in human immunodeficiency virus type 1 reverse transcriptase that confer resistance to capravirine, a novel nonnucleoside reverse transcriptase inhibitor. [J] . Sato A, Hammond J, Alexander TN, Antiviral Research . 2006,第2期

机译：对人免疫缺陷病毒1型逆转录酶中的突变进行体外选择，该突变赋予对一种新的非核苷逆转录酶抑制剂capravirine的抗性。
3. Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitor. [J] . Fletcher P, Harman S, Azijn H Antimicrobial agents and chemotherapy. . 2009,第2期

机译：候选杀微生物剂达比韦林（一种非核苷类逆转录酶抑制剂）抑制人1型免疫缺陷病毒感染。
4. Brain-Derived Neurotrophic Factor Prevents Human Immunodeficiency Prevents Human Immunodeficiency Virus Type 1 Protein gp120 Neurotoxicityin the Rat Nigrostriatal System [C] . ITALO MOCCHETTI, RACHEL L. NOSHENY, GIANLUIGI TANDA, International Conference on Neuroprotective Agents: Clinical and Experimental Aspects . 2007

机译：脑衍生的神经营养因子可防止人类免疫缺陷可防止人类免疫缺陷病毒1型蛋白GP120神经毒性素大鼠核心瘤系统
5. The effects of nonnucleoside reverse transcriptase inhibitor resistance mutations on human immunodeficiency virus type 1 replication and reverse transcriptase function. [D] . Gerondelis, Peter. 2001

机译：非核苷类逆转录酶抑制剂耐药性突变对人免疫缺陷病毒1型复制和逆转录酶功能的影响。
6. Induction of Apoptosis by a Nonnucleoside Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitor [O] . A. A. Pilon, J. J. Lum, J. Sanchez-Dardon, 2002

机译：非核苷人类免疫缺陷病毒1型逆转录酶抑制剂诱导的细胞凋亡。
7. Induction of Apoptosis by a Nonnucleoside Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitor [O] . Pilon, A. A., Lum, J. J., Sanchez-Dardon, J., 2002

机译：非核苷人类免疫缺陷病毒1型逆转录酶抑制剂诱导的细胞凋亡。

Induction of apoptosis by a nonnucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitor.

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