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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Pharmacokinetics of ampicillin and sulbactam in pediatric patients.
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Pharmacokinetics of ampicillin and sulbactam in pediatric patients.

机译：氨苄西林和舒巴坦在儿科患者中的药代动力学。

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Intravenous ampicillin-sulbactam is effective in the treatment of various infections in adults, but little is known about the pharmacokinetics (PK) of ampicillin-sulbactam in children. The objective of this study was to determine the PK of ampicillin and sulbactam in pediatric patients with intra-abdominal infection, skin and/or skin structure infection, or periorbital-preseptal and facial cellulitis. Intravenous ampicillin and sulbactam (2:1), 40 to 80 mg/kg of body weight, were given every 6 h for 2 to 6 days to 28 pediatric patients. The ages ranged from 1 to 6 years for 10 patients, 6.1 to 10 years for 9 patients, and 10.1 to 12 years for 9 patients. Multiple blood samples were obtained and analyzed for ampicillin and sulbactam in plasma and serum by high-performance liquid chromatography. The mean maximum concentration of drug in serum ranged from 177 to 200 micrograms/ml for ampicillin and 82 to 102 micrograms/ml for sulbactam in the three age groups. The mean total clearance, steady-state distribution volume, and half-life were 4.76 ml/min/kg, 0.32 liter/kg, and 0.77 h, respectively, for ampicillin and 4.95 ml/min/kg, 0.34 liter/kg, and 0.81 h, respectively, for sulbactam. Dose or gender did not affect the PK of ampicillin or sulbactam. The PK of ampicillin and sulbactam in these patients were comparable to those reported in adults. The combination was well tolerated in pediatric patients.
机译：静脉注射氨苄西林舒巴坦可有效治疗成人各种感染，但对儿童氨苄西林舒巴坦的药代动力学（PK）知之甚少。这项研究的目的是确定患有腹腔内感染，皮肤和/或皮肤结构感染，或眶前，前房间隔和面部蜂窝组织炎的儿科患者的氨苄西林和舒巴坦的PK。 28例患儿每6 h服用40至80 mg / kg体重的静脉注射氨苄青霉素和舒巴坦（2：1），持续2至6天。 10名患者的年龄为1至6岁，9名患者的年龄为6.1至10岁，9名患者的年龄为10.1至12岁。获得了多个血样，并通过高效液相色谱法分析了血浆和血清中的氨苄西林和舒巴坦。在这三个年龄组中，氨苄青霉素的血清中药物的平均最大浓度范围为177至200微克/毫升，舒巴坦的范围为82至102微克/毫升。氨苄西林的平均总清除率，稳态分布量和半衰期分别为4.76 ml / min / kg，0.32升/ kg和0.77 h，而氨苄西林的平均总清除率，稳态分布量和半衰期分别为4.95 ml / min / kg，0.34升/ kg和舒巴坦分别为0.81小时。剂量或性别均不影响氨苄西林或舒巴坦的PK。在这些患者中，氨苄西林和舒巴坦的PK与成人中报道的PK相当。该组合在儿科患者中耐受良好。

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