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首页> 外文期刊>Antimicrobial agents and chemotherapy. >Emergence and Dissemination of BEL-1-Producing Pseudomonas aeruginosa Isolates in Belgium
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Emergence and Dissemination of BEL-1-Producing Pseudomonas aeruginosa Isolates in Belgium

机译：比利时生产BEL-1的铜绿假单胞菌分离株的出现和传播

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Between May and November 2006, we identified five P. aeruginosa strains originating from patients hospitalized in five different cities (Brussels, Charleroi, Huy, Namur, and Yvoir) which showed high-level resistance to ticarcillin (no inhibition zone around the disk) and intermediate or demonstrable resistance to ceftazidime and aztreonam by the disc diffusion method according to the guidelines of the CLSI (formerly NCCLS) (1). This phenotypic resistance profile initially suggested the association with a penicillinase and a partially de-repressed cephalosporinase. The five patients had severe underlying diseases, had all been hospitalized for a long period (Table 1), and had previously received broad-spectrum antimicrobial therapy. All of the isolates were resistant to ticarcillin; four were either resistant or borderline susceptible to pip-eracillin, piperacillin-tazobactam, ceftazidime, cefepime, and aztreonam but susceptible to imipenem and meropenem by Etest MIC determination (Table 1).
机译：在2006年5月至2006年11月之间，我们鉴定出五种铜绿假单胞菌菌株，它们来自五个不同城市（布鲁塞尔，沙勒罗瓦，休伊，那慕尔和伊沃尔）的住院患者，它们对替卡西林表现出高水平的耐药性（盘周围无抑制区），根据CLSI（以前称为NCCLS）的指导，采用圆盘扩散法对头孢他啶和氨曲南具有中等或明显的耐药性。这种表型耐药性特征最初表明与青霉素酶和部分抑制的头孢菌素酶相关。这五名患者患有严重的基础疾病，都已长期住院（表1），并且以前接受过广谱抗菌治疗。所有分离株均对替卡西林耐药。四个对pip-eracillin，哌拉西林-他唑巴坦，头孢他啶，头孢吡肟和氨曲南敏感或耐药，但通过Etest MIC测定对亚胺培南和美洛培南敏感（表1）。

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