Determination of posaconazole levels in toenails of adults with onychomycosis following oral treatment with four regimens of posaconazole for 12 or 24 weeks.

Krishna G; Ma L; Martinho M; Prasad P; Wahl J; Tavakkol A

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Determination of posaconazole levels in toenails of adults with onychomycosis following oral treatment with four regimens of posaconazole for 12 or 24 weeks.

机译：口服四次泊沙康唑方案治疗12或24周后，测定成人灰指甲的脚趾甲中泊沙康唑的水平。

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Pharmacokinetic data from a randomized, parallel-group, multicenter study are presented. Adults with toenail onychomycosis (n = 146) received posaconazole (100 mg, 200 mg, or 400 mg) once daily (QD) for 24 weeks or 400 mg QD for 12 weeks. The posaconazole concentration in the great toenail exhibited a dose-related increase starting at week 2 for 24 weeks and a mean toenail-to-plasma concentration ratio of approximately 3:1 at the end of treatment for the 400-mg 24-week dose.

机译：呈现了来自随机，平行组，多中心研究的药代动力学数据。患有趾甲甲癣（n = 146）的成人每天接受一次泊沙康唑（100 mg，200 mg或400 mg）一次（QD），持续24周，或接受400 mg QD，持续12周。从第2周开始的24周内，大趾甲中的泊沙康唑浓度显示出剂量相关的增加，并且在400毫克的24周剂量治疗结束时，趾甲与血浆的平均浓度之比约为3：1。

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《Antimicrobial agents and chemotherapy.》 |2011年第9期|共3页
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Krishna G; Ma L; Martinho M; Prasad P; Wahl J; Tavakkol A;
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正文语种 eng
中图分类治疗学;
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1. Determination of posaconazole levels in toenails of adults with onychomycosis following oral treatment with four regimens of posaconazole for 12 or 24 weeks. [J] . Krishna G, Ma L, Martinho M, Antimicrobial agents and chemotherapy. . 2011,第9期

机译：口服四次泊沙康唑方案治疗12或24周后，测定成人灰指甲的脚趾甲中泊沙康唑的水平。
2. Comparison of posaconazole serum concentrations from haematological cancer patients on posaconazole tablet and oral suspension for treatment and prevention of invasive fungal infections [J] . Pham Aaron N., Bubalo Joseph S., Lewis James S. II Mycoses: Diagnosis, therapy and prophylaxis of fungal diseases . 2016,第4期

机译：普沙康唑片和口服混悬液用于治疗和预防侵袭性真菌感染的血液癌症患者的泊沙康唑血清浓度比较
3. Treatment by Posaconazole Tablets, Compared to Posaconazole Suspension, Does Not Reduce Variability of Posaconazole Trough Concentrations [J] . Gautier-Veyret Elodie, Bolcato Lea, Roustit Matthieu, Antimicrobial agents and chemotherapy. . 2019,第10期

机译：与posaconazole悬浮液相比，posaconazole片剂的处理不会降低posaconazole槽浓度的可变性
4. Determination of the Antifungal Posaconazole in Human Fingernails and Toenails Using Liquefaction, Liquid-Liquid Extraction, Liquid Chromatography and Mass Spectrometric Detection [C] . Mark Leahy, Michelle J. Cannon, Janet Nelson, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：使用液化，液液萃取，液相色谱和质谱检测测定人指甲和趾甲中的抗真菌酰唑烷唑
5. The Effect of Tailored Provider-Patient Communication on Oral Health Literacy Levels in Adults. [D] . Krob, Jamillee L. 2015

机译：量身定制的提供者-患者沟通对成人口腔健康素养水平的影响。
6. Determination of Posaconazole Levels in Toenails of Adults with Onychomycosis following Oral Treatment with Four Regimens of Posaconazole for 12 or 24 Weeks [O] . Gopal Krishna, Lei Ma, Monika Martinho, 2011

机译：口服四种泊沙康唑方案治疗12周或24周后成人甲癣的脚趾甲中泊沙康唑的含量测定
7. Determination of Posaconazole Levels in Toenails of Adults with Onychomycosis following Oral Treatment with Four Regimens of Posaconazole for 12 or 24 Weeks▿ [O] . Krishna, Gopal, Ma, Lei, Martinho, Monika, 2011

机译：口服四种泊沙康唑治疗12周或24周后，成人灰指甲的脚趾甲中泊沙康唑的含量测定▿

Determination of posaconazole levels in toenails of adults with onychomycosis following oral treatment with four regimens of posaconazole for 12 or 24 weeks.

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