Anti-HAV activity of some newly synthesized triazolo(4,3-b)pyridazines.

Shamroukh AH; Ali MA

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Anti-HAV activity of some newly synthesized triazolo(4,3-b)pyridazines.

机译：一些新合成的三唑并（4,3-b）哒嗪的抗HAV活性。

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6-Phenyl-[1,2,4]triazolo[4,3-b]pyridazine-3(2H)-thione 2 was used as precursor for the preparation of some novel 3-S-substituted-6-phenyl-[1,2,4]triazolo[4,3-b]pyridazine derivatives 3-11. Furthermore, the preparation of 1-[2-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl)-acetyl]-1H-pyrazole derivative 13 and 5-(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanylmethyl)-[1,3,4]oxadiazole derivatives 15 and 17, are described. Some of the prepared products revealed a promising antiviral activity against hepatitis-A virus (HAV, MBB-cell culture adapted strain). Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with the test compounds. Compound 15 showed the highest effect on HAV compared to the other tested compounds.

机译：6-苯基-[1,2,4]三唑并[4,3-b]哒嗪-3（2H）-硫酮2被用作制备某些新型3-S-取代的6-苯基-[1]的前体，2,4]三唑并[4,3-b]哒嗪衍生物3-11。此外，制备1- [2-（6-苯基-[1,2,4]三唑并[4,3-b]哒嗪-3-基硫烷基）-乙酰基] -1H-吡唑衍生物13和5-（6描述了-苯基-[1,2,4]三唑并[4,3-b]哒嗪-3-基硫烷基甲基）-[1,3,4]恶二唑衍生物15和17。一些制备的产品显示出对甲型肝炎病毒（HAV，MBB细胞培养适应株）的抗病毒活性。噬斑减少感染性测定法用于确定由于用测试化合物处理而导致的病毒计数减少。与其他测试化合物相比，化合物15对HAV的影响最大。

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《Archiv der Pharmazie》 |2008年第4期|共8页
作者
Shamroukh AH; Ali MA;
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正文语种 eng
中图分类药学;
关键词
Hepatitis A Virus; pyridazine; Reduction (chemical);

机译：甲型肝炎病毒;哒嗪;还原（化学）;

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1. Anti-HAV activity of some newly synthesized triazolo(4,3-b)pyridazines. [J] . Shamroukh AH, Ali MA Archiv der Pharmazie . 2008,第4期

机译：一些新合成的三唑并（4,3-b）哒嗪的抗HAV活性。
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机译：雄激素受体拮抗剂和一些新合成的熔融吡唑并三唑并噻唑并嘧啶衍生物的抗前列腺癌活性
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机译：一些新合成的取代稠合吡唑并 - ，三唑并 - 噻唑并嘧啶衍生物的雄激素受体拮抗剂和抗前列腺癌活性

Anti-HAV activity of some newly synthesized triazolo(4,3-b)pyridazines.

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