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Does the Serum Metallothionein Level Reflect the Stage of Testicular Germ Cell Tumor?

机译：血清金属硫蛋白水平是否反映了睾丸生殖细胞肿瘤的阶段？

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Increased levels of metallothionein (MT) have recently been found in the blood serum of men with newly diagnosed testicular genii cell tumors (TGCT). In light of previously published results, the aim of this study was to investigate the difference in serum MT levels among patients with different stages of TGCT and compare MT with commonly used markers (alpha-fetoprotein, beta-human chorionic gonadotropin and lactate dehydrogenase). The concentration of total MT was determined in the serum of 25 men with TGCT (seminoma or non-seminoma) by differential pulse voltammetry. Serum samples were obtained prior to chemotherapy, after two cycles of chemotherapy and 1 year after chemotherapy. A statistically significant difference in MT levels in patients with different stages of TGCT was observed in the serum of patients with non-seminoma obtained before chemotherapy. Although not significant, an increase in serum MT levels commensurate with the disease stage increase was also observed in patients with seminomatous TGCT. The results indicate that, in combination with the existing markers, MT could be useful for the identification of the histological type of tumor and stage of the disease before biopsy diagnosis. (C) 2016 IMSS. Published by Elsevier Inc.
机译：最近在患有新诊断的睾丸生殖器细胞瘤（TGCT）的男性血清中发现金属硫蛋白（MT）含量增加。根据先前发表的结果，本研究的目的是研究不同时期TGCT患者的血清MT水平差异，并将MT与常用标记（α-甲胎蛋白，β-人绒毛膜促性腺激素和乳酸脱氢酶）进行比较。用差示脉冲伏安法测定25名TGCT（血清性或非血清性）男性的血清中总MT的浓度。在化疗之前，化疗的两个周期后和化疗后的1年获得血清样品。在化疗之前获得的非精原细胞瘤患者血清中，TGCT不同阶段患者的MT水平有统计学意义的差异。尽管不显着，但在半精子性TGCT患者中还观察到血清MT水平的升高与疾病阶段的增加相称。结果表明，结合现有的标记物，MT可用于在活检诊断之前鉴定肿瘤的组织学类型和疾病阶段。 （C）2016年IMSS。由Elsevier Inc.发布

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