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首页> 外文期刊>Archives of medical research >Expression of syndecan-1 in papillary carcinoma of the thyroid with extracapsular invasion.
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Expression of syndecan-1 in papillary carcinoma of the thyroid with extracapsular invasion.

机译：syndecan-1在甲状腺乳头状癌伴囊外浸润中的表达。

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BACKGROUND AND AIMS: Syndecan-1 (SDC-1) is a member of the family of transmembrane heparan sulfate proteoglycans, which are involved in cell-cell adhesion and the interaction of cells with the extracellular matrix. Evidence suggests that loss of SDC-1 expression in several benign and malignant epithelial neoplasms is an unfavorable prognostic indicator, but its expression profile in thyroid gland neoplasms remains to be elucidated. The aim of this study was to evaluate SDC-1 expression in papillary carcinomas of the thyroid (PCT) that were both larger and smaller (papillary microcarcinoma) than 10mm, with or without extracapsular extension (PCT-E and PCT-NE). METHODS: The expression of SDC-1 was studied in 62 cases of PCT-E and PCT-NE using a tissue microarrays technique (TMA). SDC-1 positivity was predominantly observed in the cytoplasm of neoplastic epithelial cells and in the stroma of PCT. RESULTS: SDC-1 is expressed in both neoplastic epithelial cells and the stroma. It is more frequently expressed in PCT-E than PCT-NE (p=0.002) and the stromal expression of SDC-1 is more intense in PCT-E that are >10 mm (p=0.026). CONCLUSIONS: The epithelial and stromal expression of SDC-1 observed in this series of PCT suggests that the expression of this protein may be related to extracapsular invasion.
机译：背景与目的：Syndecan-1（SDC-1）是跨膜硫酸乙酰肝素蛋白聚糖家族的一员，其参与细胞与细胞的粘附以及细胞与细胞外基质的相互作用。有证据表明，在一些良性和恶性上皮肿瘤中SDC-1表达的丧失是不利的预后指标，但其在甲状腺腺肿瘤中的表达情况仍有待阐明。这项研究的目的是评估SDC-1在大于或小于10mm的甲状腺乳头状癌（PCT）中（无论有无囊外延伸）（PCT-E和PCT-NE）都表达。方法：采用组织微阵列技术（TMA）研究了62例PCT-E和PCT-NE中SDC-1的表达。主要在肿瘤上皮细胞的细胞质和PCT基质中观察到SDC-1阳性。结果：SDC-1在肿瘤上皮细胞和间质中均有表达。它在PCT-E中比在PCT-NE中更频繁地表达（p = 0.002），并且SDC-1的基质表达在PCT-E中> 10 mm时更加强烈（p = 0.026）。结论：在该系列PCT中观察到的SDC-1的上皮和基质表达表明该蛋白的表达可能与囊外侵袭有关。

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