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首页> 外文期刊>Archives of dermatological research. >Polyphenon-60 displays a therapeutic effect on acne by suppression of TLR2 and IL-8 expression via down-regulating the ERK1/2 pathway
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Polyphenon-60 displays a therapeutic effect on acne by suppression of TLR2 and IL-8 expression via down-regulating the ERK1/2 pathway

机译：Polyphenon-60通过下调ERK1 / 2途径抑制TLR2和IL-8表达，从而对痤疮具有治疗作用。

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Propionibacterium acnes (P. acnes) is a wellknown acne-inducing factor which causes inflammatory skin lesions by enhancing cytokine production through toll-like receptor 2 (TLR2). Green tea extract catechin has been documented to possess anti-inflammatory effects. However, little is known about the mechanisms involved or any direct effect of green tea catechin on acne. The present study investigated the therapeutic effects and mechanism of polyphenon-60, also known as green tea catechin compound, on acne in vitro and in vivo. In a clinical study using topical polyphenon-60 treatment, acne patients showed symptomatic improvement with decrease in the number of comedos and pustules. To investigate the mechanism underlying the activity of polyphenon-60 in acne therapy, an in vitro study was performed. We found that polyphenon-60 reduced the levels of P. acnes-enhanced TLR2 and interleukin-8 (IL-8) in THP-1 cells, human monocyte cell line and human primary monocytes. Taken together, these data demonstrate that polyphenon-60 has a therapeutic effect on acne by suppressing inflammation, specifically by inhibiting TLR2 expression and IL-8 secretion via down-regulation of extracellular signal-regulated kinases 1/2 (ERK1/2) pathway and activator protein-1 (AP-1) pathway.
机译：痤疮丙酸杆菌（痤疮丙酸杆菌）是一种众所周知的痤疮诱导因子，其通过增加通行费样受体2（TLR2）产生的细胞因子来引起炎症性皮肤损伤。绿茶提取物儿茶素已被证明具有抗炎作用。但是，关于绿茶儿茶素对痤疮的作用机理或任何直接作用知之甚少。本研究调查了polyphenon-60（也称为绿茶儿茶素化合物）在体外和体内对痤疮的治疗作用和机理。在一项使用局部多酚60治疗的临床研究中，痤疮患者表现出症状改善，且痤疮和脓疱数量减少。为了研究痤疮治疗中polyphenon-60活性的潜在机制，进行了一项体外研究。我们发现polyphenon-60降低了THP-1细胞，人单核细胞系和人原代单核细胞中痤疮丙酸杆菌增强的TLR2和白介素8（IL-8）的水平。综上所述，这些数据表明，polyphenon-60通过抑制炎症，特别是通过下调细胞外信号调节激酶1/2（ERK1 / 2）途径抑制TLR2表达和IL-8分泌，从而对痤疮具有治疗作用。激活蛋白1（AP-1）途径。

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