• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archives of dermatological research. >The correlation between monocyte chemoattractant protein-1 and the arthritis of systemic lupus erythematosus among Chinese.
【24h】

The correlation between monocyte chemoattractant protein-1 and the arthritis of systemic lupus erythematosus among Chinese.

机译：中国人单核细胞趋化蛋白-1与系统性红斑狼疮关节炎的相关性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Monocyte chemoattractant protein-1 (MCP1) polymorphism has been reported to be associated with systemic lupus erythematosus (SLE). However, the correlation between the polymorphism and SLE is poorly understood. In this study we investigated the role of this polymorphism together with that of chemokine SDF1-3'A and chemokine receptor CCR2-V64I. The association between gene polymorphism and SLE was explored by way of a case-control study. In 143 patients with SLE and 157 healthy controls, the polymorphisms of SDF1-3'A, -2518MCP-1 and CCR2-V64I were determined using PCR-RFLP and an amplification-refractory mutation system, respectively. No significant difference was found in allelic and genotype frequency of SDF1-3'A, CCR2-V64I and -2518MCP-1 between SLE patients and controls. However, a significant increase in the frequency of the AG genotype of MCP-1 was found among patients with arthritis (P(c)=0.003, OR 3.08, 95%CI 1.27-7.57). The frequency of individuals having G at position -2518 of the MCP-1 gene was also increased among patients with arthritis (P(c)=0.028, OR 2.99, 95%CI 1.13-8.08). It is noteworthy that the frequency of -2518MCP-1G in the Chinese Han population was 64%. The results indicate an association between the presence of G at position -2518 in the MCP-1 promoter region and the presence of arthritis in patients with SLE.
机译：据报道单核细胞趋化蛋白-1（MCP1）多态性与系统性红斑狼疮（SLE）有关。但是，人们对多态性与SLE之间的相关性了解甚少。在这项研究中，我们调查了这种多态性以及趋化因子SDF1-3'A和趋化因子受体CCR2-V64I的作用。通过病例对照研究探索了基因多态性与SLE之间的关联。在143例SLE患者和157例健康对照者中，分别使用PCR-RFLP和扩增-难治性突变系统确定了SDF1-3'A，-2518MCP-1和CCR2-V64I的多态性。在SLE患者和对照组之间，SDF1-3'A，CCR2-V64I和-2518MCP-1的等位基因和基因型频率没有显着差异。但是，在患有关节炎的患者中，MCP-1 AG基因型的频率显着增加（P（c）= 0.003，OR 3.08，95％CI 1.27-7.57）。在患有关节炎的患者中，MCP-1基因-2518位具有G的个体的频率也增加了（P（c）= 0.028，OR 2.99、95％CI 1.13-8.08）。值得注意的是，中国汉族人口中-2518MCP-1G的发生率为64％。结果表明，在SLE患者中，MCP-1启动子区域中-2518位G的存在与关节炎的存在相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号