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首页> 外文期刊>Archives of dermatological research. >Polymorphisms of tumor necrosis factor (TNF) alpha and beta genes in Korean patients with psoriasis.
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Polymorphisms of tumor necrosis factor (TNF) alpha and beta genes in Korean patients with psoriasis.

机译：韩国银屑病患者的肿瘤坏死因子（TNF）α和β基因多态性。

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摘要

To evaluate the association of TNF-alpha (TNFA) and TNF-beta (TNFB) polymorphisms with psoriasis in the Korean population, we investigated TNF-alpha -238 and -308 promoter region and TNF-beta NcoI polymorphism using PCR-RFLP in 103 Korean psoriasis patients and 125 normal controls. The carriage and allele frequencies of TNFB*2 were significantly increased in patients with psoriasis compared with normal controls. However, TNFB*1/1 homozygote and TNFB*1 allele were significantly decreased in the patients. There were no significant differences in the polymorphism of TNF-alpha promoter -238 and -308 between the patients and controls. We also analyzed the frequencies of TNFB alleles according to the clinical characteristics of the psoriasis patients, but no significant differences were found. However, female patients with early-onset psoriasis showed an association with the TNFB*2 allele. In conclusion, our results suggest that polymorphisms of the TNFB gene may contribute to a predisposition to psoriasis in the Korean population.
机译：为了评估韩国人群中牛皮癣的TNF-alpha（TNFA）和TNF-beta（TNFB）多态性的关联，我们在103中使用PCR-RFLP研究了TNF-alpha -238和-308启动子区域以及TNF-beta NcoI多态性。韩国牛皮癣患者和125名正常对照。与正常对照相比，牛皮癣患者的TNFB * 2携带和等位基因频率显着增加。然而，患者中的TNFB * 1/1纯合子和TNFB * 1等位基因显着降低。患者和对照之间的TNF-α启动子-238和-308的多态性没有显着差异。我们还根据牛皮癣患者的临床特征分析了TNFB等位基因的频率，但未发现明显差异。但是，患有早发性牛皮癣的女性患者显示与TNFB * 2等位基因相关。总之，我们的研究结果表明，TNFB基因的多态性可能有助于韩国人群牛皮癣的易感性。

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