首页> 外文期刊>Archives of disease in childhood. Fetal and neonatal edition >Improving antibiotic prescribing in neonatal units: time to act.
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Improving antibiotic prescribing in neonatal units: time to act.

机译:改善新生儿单位的抗生素处方:采取行动的时间。

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摘要

Antibiotics are increasingly prescribed in the peripartum period, for both maternal and fetal indications. Their effective use can be life-saving, however, injudicious use drives antibiotic resistance and contributes to the development of abnormal faecal flora and subsequent immune dysregulation. Neonatal units are a high risk area for the selection and transmission of multi-resistant organisms. Very few new antibiotics with activity against Gram-negative bacteria are under development, and no significantly new Gram-negative antibiotics will be available in the next decade. This review seeks to summarise current practice, and suggests restrictive antibiotic strategies based on epidemiological data from recently published UK neonatal infection surveillance studies.
机译:围产期越来越多地针对母亲和胎儿的适应症开抗生素。它们的有效使用可以挽救生命,但是,不正确的使用会驱动抗生素耐药性,并导致异常粪便菌群的发展和随后的免疫失调。新生儿单位是选择和传播多重抗性生物的高风险领域。具有抗革兰氏阴性菌活性的新抗生素极少开发,并且在未来十年内将不会有明显新的革兰氏阴性抗生素。这篇综述旨在总结当前的实践,并基于最近发表的英国新生儿感染监测研究的流行病学数据,提出限制性抗生素策略。

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