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首页> 外文期刊>Archives des sciences >Role of residual antibiotics in aquatic environment on the selection and diffusion of bacterial resistances of Aeromonas, Acinetobacter and Legionella.
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Role of residual antibiotics in aquatic environment on the selection and diffusion of bacterial resistances of Aeromonas, Acinetobacter and Legionella.

机译：水生环境中残留抗生素对气单胞菌，不动杆菌和军团菌的耐药性选择和扩散的作用。

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Role of residual antibiotics in aquatic environment on the selection and diffusion of bacterial resistances of Aeromonas, Acinetobacter and Legionella. - Antibiotic resistant bacteria and antibiotics are discharged in various amounts in the environment as a result of the increasing and often indiscriminate use of antibiotics in medical veterinary and agricultural practices. Surface waters are the main receptacle for these pollutants and are the major source of water directly or indirectly used for human and animal consumption. The aim of this study, carried out within the National Research Program 49 "Antibiotic Resistance", was to evaluate the role of residual antibiotic compounds in water on emergence and persistence of resistant bacteria. Research was focused on three bacterial genera, Aeromonas, Acinetobacter, and Legionella, largely diffused in the aquatic environment and showing pathogenic properties towards human beings and animals, and three antibiotic families (beta-lactams, quinolones / fluoroquinolones and macrolides) mainly used in human medicine. Phenotypic resistance analysis in various aquatic environments has highlighted the presence of resistant stains in the most contaminated waters. Aeromonas resistant to the fourth generation cephalosporins could be isolated from hospital waste waters and from waste water treatment plants, while clinical strains proved to be more susceptible. On the contrary, environmental Acinetobacter were more susceptible than those of clinical origin. For Legionella strains, MIC values were different according to the genetic type (Sequence-based Type) and not according to the origin. A significant correlation between concentrations of antibiotic compounds measured and resistant Aeromonas and Acinetobacter strains was highlighted in hospital waste waters. Finally, the diffusion of class 1 integrons, genetic and mobile element, in Aeromonas strains isolated from various aquatic environments were evaluated and correlated with their origin.
机译：水生环境中残留抗生素对气单胞菌，不动杆菌和军团菌的耐药性选择和扩散的作用。 -由于在兽医和农业实践中抗生素的使用越来越多，而且经常不加区分地使用，导致抗生素耐药性细菌和抗生素在环境中的排放量不同。地表水是这些污染物的主要容器，也是直接或间接用于人类和动物消费的主要水源。在国家研究计划49“抗生素抗性”中进行的这项研究的目的是评估水中残留的抗生素化合物对耐药菌的出现和持久性的作用。研究的重点是三个细菌属，气单胞菌，不动杆菌和军团菌，它们在水生环境中广泛传播并显示出对人类和动物的致病特性，以及三个主要用于人类的抗生素家族（β-内酰胺类，喹诺酮类/氟喹诺酮类和大环内酯类）。药物。在各种水生环境中进行的表型耐药性分析突显了在污染最严重的水域中存在耐药性污渍的情况。可以从医院废水和废水处理厂中分离出对第四代头孢菌素具有抗性的气单胞菌，而临床菌株被证明更易感。相反，环境不动杆菌比临床来源的不动杆菌更易感染。对于军团菌菌株，MIC值根据遗传类型（基于序列的类型）而不是根据来源而不同。医院废水中突出显示了所测抗生素化合物的浓度与耐药性气单胞菌和不动杆菌菌株之间的显着相关性。最后，评估了从各种水生环境中分离出的气单胞菌菌株中1类整合素，遗传和移动元件的扩散，并将其与其起源相关联。

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