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首页> 外文期刊>Journal of basic and clinical physiology and pharmacology >Drug combinations in diabetic neuropathic pain: an experimental validation
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Drug combinations in diabetic neuropathic pain: an experimental validation

机译：在糖尿病神经性疼痛的药物组合:一个实验验证

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摘要

Background: Diabetic neuropathy is the most common complication of diabetes mellitus, and the different drug combinations available do not provide effective pain relief. The present study was performed to observe the effect of amitripyline, duloxetine, sitagliptin, and pregabalin, and their combinations on streptozotocin (STZ)-induced diabetic neuropathy. Methods: Diabetic neuropathy was induced by STZ, and the tail-flick test was used to assess thermal hyperalgesia before and after (at 30, 60, and 120 min) drug administration. One week after STZ administration, the blood glucose level was observed to be in the diabetic range. Results: Administration of all the drugs except sitagliptin increased the tail-flick latency significantly as compared to control. Further, the drugs amitriptyline, duloxetine, and pregabalin showed significant pain-relieving effect, when either two of them were administered in combination, although the different combinations had varied degree of pain relief. However, sitagliptin was observed to have no effect when administered alone or in combination with the other three drugs. Conclusions: Therefore, the study provides new insights concerning combined therapy of pain, which further needs clinical exploration.
机译：背景:糖尿病神经病变是最常见的糖尿病的并发症,不同药物组合并不可用提供有效的缓解疼痛。进行观察的影响amitripyline,度洛西汀,sitagliptin和普瑞巴林及其组合链脲霉素(STZ)全身的糖尿病神经病变。方法:由STZ诱导糖尿病性神经病变,和tail-flick测试是用来评估之前和之后的热痛觉过敏(30、60和120分钟)药品监督管理局。STZ管理、血糖水平观察糖尿病范围。所有的药物,除了管理工作sitagliptin增加了tail-flick延迟明显比控制。药物阿米替林、度洛西汀和普瑞巴林显示显著缓解疼痛效果,当两个管理结合在一起,虽然不同组合有不同程度的缓解疼痛。然而,sitagliptin观察到没有当单独或者联合管理的效果与其他三种药物。因此,这项研究提供了新的见解关于联合治疗的痛苦,进一步需要临床探索。

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