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首页> 外文期刊>Archives of microbiology >Mutations in cell division proteins FtsZ and FtsA inhibit phi X174 protein-E-mediated lysis of Escherichia coli
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Mutations in cell division proteins FtsZ and FtsA inhibit phi X174 protein-E-mediated lysis of Escherichia coli

机译：细胞分裂蛋白FtsZ和FtsA的突变抑制phi X174蛋白-E介导的大肠杆菌裂解

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Electron microscopic studies emphasized that the protein-E-specific transmembrane tunnel structure, which permeabilizes Escherichia coli, is not randomly distributed over the cell envelope but is restricted to areas of potential division sites. These sites were located predominantly in the middle of the cell, but approximately one-third of these structures are found at the polar sites. Therefore, E. coli mutant strains with defects in cell division components were tested for their sensitivity to protein-E-mediated lysis. The ftsZ84 and the ftsA12 cell division mutant strains of E. coli were tolerant to protein-E-mediated lysis, whereas the ftsA3 mutant strain was lysed by protein E under conditions nonpermissive for division. The protein-E-tolerant phenotype of ftsZ84 and ftsA12 and the lysis-sensitive phenotype of other components of the septosome (e.g.,ftsA3, ftsQ, and ftsl) suggest that initiation of cell division - rather than specific functions of cell division - plays an essential role in protein-E-mediated lysis. SulA-overproducing cells had a lysis-positive phenotype, the ring structure - but not the GTPase function - of FtsZ was impaired. [References: 54]
机译：电子显微镜研究强调，可渗透大肠杆菌的蛋白E特异跨膜通道结构并非随机分布在细胞膜上，而是局限于潜在的分裂位点区域。这些位点主要位于细胞的中间，但是这些结构的大约三分之一位于极点。因此，测试了具有细胞分裂成分缺陷的大肠杆菌突变菌株对蛋白质-E介导的裂解的敏感性。大肠杆菌的ftsZ84和ftsA12细胞分裂突变株可耐受蛋白E介导的裂解，而ftsA3突变株在不容许分裂的条件下被蛋白E裂解。 ftsZ84和ftsA12的蛋白质E耐受表型以及隔膜体其他成分（例如ftsA3，ftsQ和fts1）的裂解敏感性表型表明，细胞分裂的启动而非细胞分裂的特定功能在蛋白质E介导的裂解中起重要作用。过量生产SulA的细胞具有裂解阳性表型，FtsZ的环结构（而非GTPase功能）受损。 [参考：54]

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