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首页> 外文期刊>Archives of Toxicology >An in vivo assessment of the genotoxic potential of bisphenol A and 4-tert-octylphenol in rats.
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An in vivo assessment of the genotoxic potential of bisphenol A and 4-tert-octylphenol in rats.

机译：在体内评估双酚A和4-叔辛基苯酚在大鼠中的遗传毒性潜力。

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摘要

Bisphenol A (BPA) and octylphenol (OP) are industrial chemicals used in the manufacture of polycarbonate plastics, epoxy resins, and non-ionic surfactants. In the present study, we investigated the possible in vivo genotoxic effects of these compounds in rats using single-cell gel electrophoresis, the so-called comet assay. Adult male Wistar albino rats were divided randomly into six groups as follows: BPA125 (received 125 mg/kg bw BPA; n = 6), OP125 (received 125 mg/kg bw OP; n = 6), BPA250 (received 250 mg/kg BPA; n = 6), OP250 (received 250 mg/kg bw OP; n = 6), control (n = 5), and MMS (positive control group that received methyl methanesulfonate; n = 3). Both BPA and OP were orally administrated for 4 weeks. Controls were orally inoculated with corn oil for 4 weeks as well. Comet parameters including tail length and tail moment were evaluated for possible genotoxic effects. There were no significant differences in the OP125 and in the BPA125 compared with the control group, regarding tail length and tail moment (P > 0.05). However, there were significant differences in the OP250 and in the BPA250 compared with the control group, regarding tail length and tail moment (P < 0.05 and P < 0.01, respectively). The genotoxic potential of BPA and OP was investigated in vivo; there is a need for further studies exploring further mechanisms of the genotoxic potential of these chemicals in vivo.
机译：双酚A（BPA）和辛基酚（OP）是用于制造聚碳酸酯塑料，环氧树脂和非离子表面活性剂的工业化学品。在本研究中，我们使用单细胞凝胶电泳（所谓的彗星试验）研究了这些化合物在大鼠体内的可能的遗传毒性作用。将成年雄性Wistar白化病大鼠随机分为六组：BPA125（体重为125 mg / kg bw; n = 6）; OP125（体重为125 mg / kg bw; n = 6）; BPA250（体重为250 mg / kg） kg BPA; n = 6），OP250（接受250 mg / kg bw OP; n = 6），对照组（n = 5）和MMS（接受甲磺酸甲酯的阳性对照组; n = 3）。 BPA和OP均口服给药4周。对照也口服玉米油4周。评估彗星参数，包括尾巴长度和尾矩，以了解可能的遗传毒性作用。与对照组相比，OP125和BPA125在尾巴长度和尾矩方面无显着差异（P> 0.05）。但是，OP250和BPA250与对照组相比在尾巴长度和尾矩方面存在显着差异（分别为P <0.05和P <0.01）。在体内研究了BPA和OP的遗传毒性潜力;有必要进行进一步的研究，以探索这些化学物质在体内的潜在遗传毒性的进一步机制。

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