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首页> 外文期刊>Arthritis care & research >Clinical and radiographic distribution of structural damage in erosive and nonerosive hand osteoarthritis
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Clinical and radiographic distribution of structural damage in erosive and nonerosive hand osteoarthritis

机译：侵蚀性和非侵蚀性手性骨关节炎的结构损伤的临床和影像学分布

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摘要

Objective. To characterize the clinical and radiographic joint phenotype in erosive hand osteoarthritis (EHOA) and non-EHOA. Methods. A total of 446 patients with HOA (233 with EHOA and 213 with non-EHOA) were evaluated. Demographic (sex and age at disease onset), clinical (body mass index and distribution of nodes), and radiographic features (Kellgren/Lawrence and Kallman's scores obtained from radiographs of both hands) from all patients were recorded. Results. Patients with EHOA had a significantly earlier disease onset. Clinical and radiographic distribution of structural damage in the distal interphalangeal (DIP), proximal interphalangeal (PIP), and first carpometacarpal joints was similar in EHOA and non-EHOA. EHOA patients showed higher percentages of nodes and more severe radiographic scores; the more severe radiographic score of joints with nodes was due to both osteophytes and joint space narrowing (JSN). A direct correlation between osteophytes and JSN scores was observed. Central erosions (CE) were more prevalent in the DIP joints than in the PIP joints. Gull-wing pattern of CE was prevalent in the DIP joints, whereas saw-tooth pattern was prevalent in the PIP joints. Marginal erosions (ME) were present in 100% of EHOA patients and in 80% of non-EHOA patients. An ordinal correlation between the presence of ME and osteophyte score was found. Conclusion. We found quantitative, but not topographic, differences in structural damage between EHOA and non-EHOA. Heberden's nodes, severe radiologic scores, and CE were concentrated in the second, third, and fifth DIP joints of both hands. ME were also present in the majority of non-EHOA patients.
机译：目的。表征侵蚀性手骨关节炎（EHOA）和非EHOA的临床和影像学联合表型。方法。总共评估了446例HOA患者（233例为EHOA，213例为非EHOA）。记录所有患者的人口统计资料（疾病发作时的性别和年龄），临床资料（体重指数和结节分布）和影像学特征（从两只手的X光片获得的Kellgren / Lawrence和Kallman评分）。结果。患有EHOA的患者发病明显较早。在EHOA和非EHOA中，远端指间（DIP），近端指间（PIP）和第一腕掌关节的结构损伤的临床和影像学分布相似。 EHOA患者显示出更高的淋巴结百分比和更严重的放射学评分;有结节的关节的放射学评分更严重是由于骨赘和关节间隙变窄（JSN）所致。观察到骨赘与JSN得分之间存在直接相关性。 DIP关节中的中央侵蚀（CE）比PIP关节中更普遍。 CE的鸥翼型在DIP关节中普遍存在，而锯齿形在PIP关节中普遍存在。 100％的EHOA患者和80％的非EHOA患者都存在边缘侵蚀（ME）。发现ME的存在与骨赘评分之间存在序数相关性。结论。我们发现EHOA和非EHOA之间的结构性损害存在定量差异，但没有地形差异。 Heberden的淋巴结，严重的放射学评分和CE集中在两只手的第二，第三和第五DIP关节中。大多数非EHOA患者中也存在ME。

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