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首页> 外文期刊>Arthritis care & research >Association between inflammatory biomarkers and bone mineral density in a community-based cohort of men and women
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Association between inflammatory biomarkers and bone mineral density in a community-based cohort of men and women

机译：社区男女队列中炎症生物标志物与骨矿物质密度之间的关联

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Objective Based upon evidence in animal and in vitro studies, we tested the hypothesis that higher serum concentrations of the cytokines interleukin-6 (IL-6) and tumor necrosis factor α (TNFα) and the inflammatory marker C-reactive protein (CRP) would be inversely associated with bone mineral density (BMD) in a community-based cohort of men and women, with the strongest associations among postmenopausal women not receiving menopause hormonal therapy (MHT). Methods We ascertained fasting serum concentrations of IL-6, TNFα, and CRP and measured BMD at the femoral neck, trochanter, total femur, and spine (L2-L4) using dual x-ray absorptiometry in 2,915 members of the Framingham Offspring Study (1996-2001). We used multivariable linear regression to estimate the difference (β) in BMD at each bone site associated with a 1-unit increase in log-transformed serum concentrations of IL-6, TNFα, and CRP separately for men (n = 1,293), premenopausal women (n = 231), postmenopausal women receiving MHT (n = 498), and postmenopausal women not receiving MHT (n = 893). Results Inflammatory biomarkers were not associated with BMD in men. Among premenopausal women, there were statistically significant, modest inverse associations between IL-6 and trochanter BMD (β = -0.030, P < 0.01) and between CRP and femoral neck (β = -0.015, P = 0.05) and trochanter BMD (β = -0.014, P = 0.04). TNFα was positively associated with spine BMD (β = 0.043, P = 0.01). In postmenopausal women receiving MHT, CRP was positively associated with femoral neck BMD (β = 0.011, P = 0.04). There were no associations among postmenopausal women not receiving MHT. Conclusion The lack of consistency in our results suggests that elevated circulating concentrations of inflammatory biomarkers may not be a risk factor for low BMD.
机译：目的基于动物和体外研究的证据，我们检验了以下假设：较高的血清细胞因子IL-6（IL-6）和肿瘤坏死因子α（TNFα）以及炎性标志物C反应蛋白（CRP）的浓度在以社区为基础的男女队列研究中，与骨矿物质密度（BMD）呈负相关，绝经后妇女未接受绝经激素治疗（MHT）的关联最强。方法我们采用双重X射线吸收法在2 915名弗雷明汉后代研究（Framingham Offspring Study）中确定了空腹血清IL-6，TNFα和CRP的浓度，并通过双X线吸收法测量了股骨颈，转子，总股骨和脊柱（B2-L4）的BMD（ 1996-2001）。我们使用多变量线性回归来估计绝经前男性（n = 1,293）分别对数转化的血清IL-6，TNFα和CRP的血清浓度增加1个单位会导致每个骨部位BMD的差异（β）。女性（n = 231），绝经后妇女接受MHT（n = 498）和绝经后妇女未接受MHT（n = 893）。结果炎症生物标志物与男性骨密度无关。在绝经前妇女中，IL-6与转子粗骨密度（β= -0.030，P <0.01）之间以及CRP与股骨颈之间（β= -0.015，P = 0.05）与转子粗骨密度（β之间）有统计学意义的适度逆相关= -0.014，P = 0.04）。 TNFα与脊柱BMD正相关（β= 0.043，P = 0.01）。在接受MHT的绝经后妇女中，CRP与股骨颈BMD正相关（β= 0.011，P = 0.04）。没有接受MHT的绝经后妇女之间没有关联。结论：我们的结果缺乏一致性，表明循环升高的炎症生物标志物浓度可能不是降低BMD的危险因素。

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