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首页> 外文期刊>Artificial Organs >Comparison between intermittent and continuous measurement of cardiac output after acute normovolemic hemodilution in pigs.
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Comparison between intermittent and continuous measurement of cardiac output after acute normovolemic hemodilution in pigs.

机译：急性等容性血液稀释后猪间歇性和连续性心输出量的比较。

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摘要

Continuous cardiac output (CO) and mixed venous oxygen saturation (SvO(2)) determined through the pulmonary artery catheter may be helpful in monitoring hemodynamic conditions in critically ill patients. This study aimed to evaluate CO and SvO(2) in a model of acute normovolemic hemodilution (ANH), analyzing the accuracy of the continuous versus intermittent method for CO and SvO(2) measurement in pigs. Twenty-three pigs were enrolled to three groups: control, ANH with 6% hydroxyethyl starch (HES), or ANH with lactated Ringer's (LR) solution. After hemodilution, we showed that SvO(2) was reduced in both groups, mainly in LR animals (P < 0.05). Regarding the evaluation of CO, we showed an increase in both groups submitted to ANH (P < 0.05). Through Bland-Altman analysis, we showed that the continuous CO catheter presented lower values than the intermittent method after hemodilution, mainly with HES (P < 0.001), and there was no difference in the measurement of SvO(2). The ANH promoted a decrease in SvO(2) and an increase in CO values, mainly in animals submitted to hemodilution with HES. The use of continuous and intermittent (laboratory) measurement of SvO(2) showed clinical applicability and good agreement, an effect not reproduced by the CO measurement. New studies are needed to further investigate the agreement between the continuous and intermittent methods for the measurement of CO in adverse hemodynamic conditions such as ANH.
机译：通过肺动脉导管确定的连续心输出量（CO）和混合静脉血氧饱和度（SvO（2））可能有助于监测危重患者的血液动力学状况。这项研究旨在评估急性等容血液稀释（ANH）模型中的CO和SvO（2），分析连续和间歇性方法测量猪中CO和SvO（2）的准确性。将二十三只猪分为三组：对照组，含有6％羟乙基淀粉（HES）的ANH或具有乳酸林格氏（LR）溶液的ANH。血液稀释后，我们显示两组的SvO（2）均降低，主要是在LR动物中（P <0.05）。关于一氧化碳的评估，我们发现提交给ANH的两组患者都有增加（P <0.05）。通过Bland-Altman分析，我们发现连续CO导管的血液稀释后值比间歇法低，主要是HES（P <0.001），并且SvO（2）的测量值没有差异。 ANH促进SvO（2）的减少和CO值的增加，主要是在接受HES血液稀释的动物中。 SvO（2）的连续和间歇（实验室）测量的使用显示出临床适用性和良好的一致性，CO测量无法重现这一效果。需要进行新的研究来进一步研究连续和间歇性方法在不良血液动力学条件下（例如ANH）测量CO的一致性。

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