• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Artificial Organs >Development of a disposable maglev centrifugal blood pump intended for one-month support in bridge-to-bridge applications: in vitro and initial in vivo evaluation.
【24h】

Development of a disposable maglev centrifugal blood pump intended for one-month support in bridge-to-bridge applications: in vitro and initial in vivo evaluation.

机译：开发一种一次性磁悬浮离心血泵，旨在在桥对桥应用中提供为期一个月的支持：体外和初始体内评估。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

MedTech Dispo, a disposable maglev centrifugal blood pump with two degrees of freedom magnetic suspension and radial magnetic coupling rotation, has been developed for 1-month extracorporeal circulatory support. As the first stage of a two-stage in vivo evaluation, 2-week evaluation of a prototype MedTech Dispo was conducted. In in vitro study, the pump could produce 5 L/min against 800 mm Hg and the normalized index of hemolysis was 0.0054 +/- 0.0008 g/100 L. In in vivo study, the pump, with its blood-contacting surface coated with biocompatible 2-methacryloyloxyethyl phosphorylcholine polymer, was implanted in seven calves in left heart bypass. Pump performance was stable with a mean flow of 4.49 +/- 0.38 L/min at a mean speed of 2072.1 +/- 64.5 rpm. The maglev control revealed its stability in rotor position during normal activity by the calves. During 2 weeks of operation in two calves which survived the intended study period, no thrombus formation was seen inside the pump and levels of plasma free hemoglobin were maintained below 4 mg/dL. Although further experiments are required, the pump demonstrated the potential for sufficient and reliable performance and biocompatibility in meeting the requirements for cardiopulmonary bypass and 1-week circulatory support.
机译：MedTech Dispo是一种具有两个自由度磁悬浮和径向磁耦合旋转功能的一次性磁悬浮离心血泵，已开发用于1个月的体外循环支持。作为两阶段体内评估的第一阶段，对原型MedTech Dispo进行了2周评估。在体外研究中，泵对800 mm Hg的流量为5 L / min，溶血标准化指数为0.0054 +/- 0.0008 g / 100L。在体内研究中，泵的血液接触表面涂有生物相容性2-甲基丙烯酰氧基乙基磷酰胆碱聚合物被植入左心旁路的七只小牛中。泵的性能稳定，平均流量为4.49 +/- 0.38 L / min，平均速度为2072.1 +/- 64.5 rpm。磁悬浮控制显示小腿在正常活动期间其转子位置的稳定性。在两头犊牛进行了2周的手术后，这些犊牛在预定的研究期内幸存下来，在泵内未见血栓形成，血浆中无血红蛋白水平维持在4 mg / dL以下。尽管还需要进一步的实验，但该泵证明了满足体外循环和1周循环支持要求的足够，可靠的性能和生物相容性的潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号