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An integrative description of dialysis adequacy indices for different treatment modalities and schedules of dialysis.

机译：对不同治疗方式和时间表的透析充足性指标的综合描述。

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摘要

Dialysis adequacy indices that are applied for the evaluation of the efficiency of urea removal include fractional water volume cleared from urea during dialysis (KT T/V), fractional solute removal (FSR), and equivalent urea clearance (EKR). Using a constant-volume, one-compartment urea kinetic model for an anuric patient, the FSR and EKR are shown to depend on only three nondimensional parameters: (i) KT/V, where K is the dialyzer clearance for hemodialysis (HD) or peritoneal mass transport coefficient for peritoneal dialysis (PD), T is the time period of dialysis, and V is urea distribution volume; (ii) T/Tc, where Tc is the length of treatment cycle; and (iii) VD/V, where VD is the volume of dialysis fluid applied. In particular, analytical formulas for FSR and EKR, valid for HD as well as for PD, were derived as functions of these three parameters. Numerical simulations, performed using a two-compartment urea kinetic model, showed that the analytical formulas are valid also for the two-compartment model, except for short, highly effective HD, where the overestimation of FSR and EKR using the analytical formulas is however, not higher than 20 and 16%, respectively. KT T/V is equal to KT/V for HD and FSR for PD. Thus, our formulas provide an integrative description of the relationships between dialysis efficiency indices and operational dialysis parameters that is valid for all modalities and schedules of dialysis. They may be applied not only for standard HD and continuous ambulatory PD, but also for HD with circulating dialysis fluid or intermittent forms of PD.
机译：用于评估尿素去除效率的透析充分性指标包括透析过程中从尿素清除的部分水量（KT T / V），溶质清除率（FSR）和等效尿素清除率（EKR）。对于无尿患者，使用恒定体积的单室尿素动力学模型，显示FSR和EKR仅取决于三个无因次参数：（i）KT / V，其中K是血液透析（HD）的透析器清除率或腹膜透析（PD）的腹膜传质系数，T为透析时间，V为尿素分布量; （ii）T / Tc，其中Tc是治疗周期的长度; （iii）VD / V，其中VD是所施加的透析液的体积。特别是，根据这三个参数得出了对HD和PD有效的FSR和EKR分析公式。使用两室尿素动力学模型进行的数值模拟表明，该分析公式对于两室模型也有效，除了短而高效的HD之外，其中使用该分析公式高估了FSR和EKR，分别不高于20％和16％。 KT T / V等于HD的KT / V和PD的FSR。因此，我们的公式提供了对所有效率和时间表的透析都有效的透析效率指标和操作性透析参数之间关系的完整描述。它们不仅可用于标准的HD和连续非卧式PD，而且可用于循环透析液或间歇性PD的HD。

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