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Conductive Gel Increases the Small Tumor Treatment With Electrochemotherapy Using Needle Electrodes

机译：导电胶通过针电极电化学疗法增加小肿瘤治疗

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摘要

The combination of chemotherapy drugs and high electric field treatment in local cancer is named electrochemotherapy. The European Standard Operation Procedure of Electrochemotherapy (ESOPE) provides guidelines for treatment of cutaneous and subcutaneous tumors. The electrochemotherapy of numerous tumors varying in sizes is more convenient using needle electrodes. However, ESOPE recommends that needle electrodes are applied to deeper tumors. The application of needle electrodes to treatment of superficial small tumors seems to be practical in electrochemotherapy. Plate electrodes and gel improve the electrochemotherapy efficacy. This technique provides electric field homogeneity in irregularly shaped tissue structures (bulk tumors). We propose an investigation of needle electrode and gel in electrochemotherapy of superficial tumors. In vivo experiment with squamous cell carcinoma (SCC) spontaneous nodules in dog was used to validate the mathematical tissue model. The numerical model considers the tissue conductivity dependent on local electric field. Our studies demonstrated that conductive gel is important for effective treatment of superficial tumors with needle electrodes. The needle electrodes and gel presented reduction of medium current, increased the tumor-free margin, and improved the practical application in relation to plate electrode.
机译：局部癌症中化学疗法药物和高电场治疗的组合被称为电化学疗法。欧洲电化学疗法标准操作程序（ESOPE）提供了治疗皮肤和皮下肿瘤的指南。使用针状电极可以更方便地对大小不等的多种肿瘤进行化学疗法。但是，ESOPE建议将针电极应用于更深的肿瘤。针电极在浅表小肿瘤治疗中的应用似乎在电化学治疗中很实用。板状电极和凝胶可改善电化学疗法的功效。此技术可在不规则形状的组织结构（体瘤）中提供均匀的电场。我们建议对浅表肿瘤的电化学疗法中的针电极和凝胶进行研究。犬鳞状细胞癌（SCC）自发结节的体内实验用于验证数学组织模型。数值模型考虑了取决于局部电场的组织电导率。我们的研究表明，导电胶对于用针电极有效治疗浅表肿瘤很重要。针状电极和凝胶剂减少了中电流，增加了无肿瘤的余量，并改善了与板状电极有关的实际应用。

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