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首页> 外文期刊>Asia-Pacific Biotech News >Stress hormones: Good or Bad for Posttraumatic Stress Disorder risk?
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Stress hormones: Good or Bad for Posttraumatic Stress Disorder risk?

机译：应激激素：创伤后应激障碍风险的好坏？

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lucocorticoids, a group of hormones | that includes Cortisol, are considered stress hormones because their levels increase following stress. When their relationship to stress was first identified, it was shown that the release of Cortisol prepared thebody to cope with the physical demands of stress. Subsequently, high levels of Cortisol were linked to depression and other stress-related disorders, giving rise to the hypothesis that high levels of Cortisol on a long-term basis may impair the psychological capacity to cope with stress. For this reason, drugs such as mifepristone that block glucocorticoid activity, called glucocorticoid receptor antagonists, have been tested as treatments for depression. But other recent data suggest that, in animal models and in humans, elevating glucocorticoid levels may reduce the development of posttraumatic stress disorder or PTSD. This hypothesis is now supported by a new study in Biological Psychiatry. Using an animal model of PTSD, Rajnish Rao and colleaguesdemonstrate that elevated levels of glucocorticoids at the time of acute stress confers protection against the delayed enhancing effect of stress on synaptic connectivity in the basolateral amygdala and anxiety-like behavior.
机译：糖皮质激素，一组激素|包括皮质醇在内的被认为是压力激素，因为它们的水平会随着压力的增加而增加。首次确定它们与压力的关系时，表明皮质醇的释放使人体能够应付压力的生理需求。随后，高水平的皮质醇与抑郁症和其他与压力有关的疾病有关，这提出了一个假设，即长期高水平的皮质醇可能会削弱应对压力的心理能力。为此，已经测试了诸如米非司酮这样的阻断糖皮质激素活性的药物，称为糖皮质激素受体拮抗剂，作为抑郁症的治疗方法。但是其他最新数据表明，在动物模型和人类中，升高糖皮质激素水平可能会减少创伤后应激障碍或PTSD的发生。现在，这项假设得到了生物精神病学的一项新研究的支持。通过使用PTSD动物模型，Rajnish Rao及其同事证明了急性应激时糖皮质激素水平的升高可提供保护，防止应激对基底外侧杏仁核突触连接的延迟增强作用和类似焦虑的行为。

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