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首页> 外文期刊>Annals of Human Genetics >Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest).
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Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest).

机译：染色体9p21上的四个SNPS在美国高加索人群（GeneQuest）中赋予早产，家族性CAD和MI风险。

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摘要

Genome-wide association studies have separately identified four single nucleotide polymorphisms (SNPs) on chromosome 9p21 that confer susceptibility to coronary artery disease (CAD) and myocardial infarction (MI). This study presents the first analysis of these SNPs (rs10757274, rs2383206, rs2383207, and rs10757278) in a premature, familial CAD/MI population (GeneQuest). We performed a case-control analysis of the GeneQuest Caucasian population with 310 cases with premature CAD and MI (average age at onset of 40.3 +/- 5.1) and 560 non-CAD controls to determine if these SNPs are associated with risk of CAD using both the population-based and family-based association study designs. The four SNPs are significantly associated with premature and familial MI and CAD in the GeneQuest Caucasian population (allelic P= 6.61 x 10(-7) to 1.87 x 10(-8)). Sib-TDT analysis showed that three of the four SNPs could confer significant susceptibility to premature CAD and MI. These results indicate that the four SNPs on chromosome 9p21 are also associated with premature, familial CAD.
机译：全基因组关联研究已分别鉴定出9p21染色体上的四个单核苷酸多态性（SNP），它们赋予了冠状动脉疾病（CAD）和心肌梗塞（MI）易感性。这项研究提出了在早产的家族性CAD / MI人群（GeneQuest）中对这些SNP（rs10757274，rs2383206，rs2383207和rs10757278）的首次分析。我们对GeneQuest白种人人群进行了病例对照分析，分析了310例过早的CAD和MI（发病年龄平均为40.3 +/- 5.1）和560个非CAD对照，以确定这些SNP是否与使用CAD的风险相关基于人口和基于家庭的协会研究设计。在GeneQuest高加索人群中，这四个SNP与早产，家族性MI和CAD显着相关（等位基因P = 6.61 x 10（-7）至1.87 x 10（-8））。 Sib-TDT分析表明，四个SNP中的三个可以赋予明显的过早CAD和MI易感性。这些结果表明，染色体9p21上的四个SNP也与早产家族性CAD相关。

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