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首页> 外文期刊>Brain injury: BI >Working memory deficits after traumatic brain injury: catecholaminergic mechanisms and prospects for treatment -- a review.
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Working memory deficits after traumatic brain injury: catecholaminergic mechanisms and prospects for treatment -- a review.

机译：脑外伤后的工作记忆缺陷：儿茶酚胺能机制和治疗前景-综述。

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PRIMARY OBJECTIVE: To review the neural circuitry and neurochemistry of working memory and outline the evidence for working memory deficits after traumatic brain injury, and the evidence for the use of catecholaminergic agents in the amelioration of these deficits. Current knowledge gaps and research needs are identified. MAIN OUTCOMES AND RESULTS: Impairments in working memory are a core component of the cognitive deficits associated with traumatic brain injury. Recent progress in understanding the neural circuitry and neurochemistry of working memory suggests that catecholamines play a central role in the activation and regulation of working memory and thus lays a framework in which to consider the use of catecholaminergic agents (dopaminergic and alpha-2 adrenergic agonists) in the treatment of specific cognitive deficits after traumatic brain injury. CONCLUSIONS: The combined methods of cognitive neuroscience, functional brain imaging and neuropharmacology are proposed as an excellent method for studying working memory deficits. A strong rationale exists for the targeted use of catecholaminergic agonists in the treatment of working memory deficits after traumatic brain injury.
机译：目的：回顾工作记忆的神经回路和神经化学，概述脑外伤后工作记忆缺陷的证据，以及使用儿茶酚胺能药改善这些缺陷的证据。确定当前的知识差距和研究需求。主要结果和结果：工作记忆障碍是与脑外伤相关的认知缺陷的核心组成部分。在了解工作记忆的神经回路和神经化学方面的最新进展表明，儿茶酚胺在工作记忆的激活和调节中起着核心作用，因此奠定了考虑使用儿茶酚胺能药物（多巴胺能和α-2肾上腺素能激动剂）的框架。在治疗脑外伤后的特定认知功能障碍方面。结论：认知神经科学，功能性脑成像和神经药理学相结合的方法被建议作为研究工作记忆缺陷的一种很好的方法。儿茶酚胺能激动剂在创伤性脑损伤后的工作记忆缺陷的治疗中有针对性使用的强烈理由。

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