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首页> 外文期刊>Annals of Saudi medicine >Autologous bone marrow transplanation for extramedullary plasmacytoma presenting as adrenal incidentaloma.
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Autologous bone marrow transplanation for extramedullary plasmacytoma presenting as adrenal incidentaloma.

机译：自体骨髓移植用于表现为肾上腺偶发瘤的髓外浆细胞瘤。

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Extramedullary adrenal plasmacytoma (EMP) involving the adrenal glands is rarely encountered clinically. We report a A 47-year-old male who presented with bilateral adrenal incidentalomas. After confirming EMP, the patient received two consecutive autologous hematopoietic stem cell transplants (HSCT) using high-dose melphalan. Following HSCT, a serial follow-up helical CT revealed a substantial decrease in the size of both adrenal masses. Serial periodic serum protein and urine electrophoresis and immunofixation showed abrogation of a previously noted monoclonal band. At 50 months follow-up the patient was alive and well. Our patient is the first with EMP to have received an autologous HSCT, which may prove to have a role in therapy due to the immunological effect of the infused donor marrow T-lymphocytes against the clonal proliferation of abnormal plasma cells in extrammedullary sites.This case indicates that an EMP should be added to the differential diagnosis of adrenal incidentalomas.
机译：临床上很少见到涉及肾上腺的髓外肾上腺浆细胞瘤（EMP）。我们报道了一位47岁的男性患者，他患有双侧肾上腺偶发瘤。确认EMP后，该患者接受了连续两次使用大剂量美法仑的自体造血干细胞移植（HSCT）。 HSCT后，连续随访螺旋CT显示两个肾上腺肿块的大小均显着减少。连续的定期血清蛋白和尿液电泳和免疫固定显示先前注意到的单克隆谱带已被废除。在50个月的随访中，患者还活着并且健康。我们的患者是首位接受自体HSCT的EMP患者，由于输注的供体骨髓T淋巴细胞对髓外部位异常浆细胞的克隆增殖具有免疫学作用，因此可能被证明具有治疗作用。提示应在肾上腺偶发瘤的鉴别诊断中加入EMP。

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