首页> 外文期刊>Annals of Saudi medicine >Hepatocellular carcinoma in the absence of liver cirrhosis in a treated hepatitis C virus patient.
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Hepatocellular carcinoma in the absence of liver cirrhosis in a treated hepatitis C virus patient.

机译:经治疗的丙型肝炎病毒患者,在没有肝硬化的情况下发生肝细胞癌。

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A 65-year-old male patient was referred to King Faisal Hospital and Research Centre after he presented with jaundice, fever, abdominal discomfort and biochemical evidence of chronic hepatitis C virus (HCV) hepatitis with no clinical or histological evidence of cirrhosis. HCV polymerase chain reaction (PCR) was positive and HCV quantitation was 4682 cop-ies/mL. Liver function test (LFT) results were ALT 225 IU/L (reference range, 5-60 IU/L), AST 104 IU/L (reference range, 5-43 IU/L), total bilirubin 20 muml/L (reference range, 5.1-17.0 mumol/L), INR 1.2 (reference range, 0.9-1.1), and albumin 38 g/L (reference range, 35-50 g/L). Liver biopsy showed chronic hepatitis grade II, stage II portal fibrosis and no evidence of cirrhosis. Alpha-fetoprotein was 6 mugm/L. The patient completed a fuE year of combination therapy of pegulated interferon 3 million units subcutaneously 3 times/week with ribavirin 1000 mg orally daily and achieved a negative viral PCR with normal LFTs. He had 3 years of follow-up with a sustained virological response (sustained loss of detectable virus in response to antiviral therapy) and was then discharged from our clinic and instructed to follow-up at his local hospital.
机译:一名65岁的男性患者因表现出黄疸,发烧,腹部不适和慢性丙型肝炎病毒(HCV)肝炎的生化证据而没有肝硬化的临床或组织学证据后,被转介至国王费萨尔医院和研究中心。 HCV聚合酶链反应(PCR)为阳性,HCV定量为4682 cop / ies / mL。肝功能检查(LFT)结果为ALT 225 IU / L(参考范围5-60 IU / L),AST 104 IU / L(参考范围5-43 IU / L),总胆红素20 muml / L(参考)范围5.1-17.0 mumol / L),INR 1.2(参考范围0.9-1.1)和白蛋白38 g / L(参考范围35-50 g / L)。肝活检显示慢性II型肝炎,II期门脉纤维化,无肝硬化迹象。甲胎蛋白为6 mugm / L。该患者每天口服1000 mg利巴韦林,每周皮下注射3百万单位干扰素300万单位,完成联合治疗fuE年,并且LFT正常时病毒PCR阴性。他进行了3年的随访,并获得了持续的病毒学应答(由于抗病毒治疗而导致可检测到的病毒持续丢失),然后从我们的诊所出院,并指示其在当地医院进行随访。

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