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首页> 外文期刊>Breast cancer research and treatment. >Relationships between circulating hormone levels, mammographic percent density and breast cancer risk factors in postmenopausal women.
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Relationships between circulating hormone levels, mammographic percent density and breast cancer risk factors in postmenopausal women.

机译：绝经后妇女循环激素水平，乳房X线照片密度和乳腺癌危险因素之间的关系。

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BACKGROUND: Endogenous hormones and insulin-like growth factors (IGF) play a central role in breast cancer development. Mammographic density, an important breast cancer risk factor, has been associated with these biomarkers in premenopausal women. The aim of this study was to assess the relationships between circulating hormones, clinical features related to breast cancer risk and mammographic density in postmenopausal women. SUBJECTS AND METHODS: The study included 226 postmenopausal women participating in a clinical prevention trial. We performed baseline measurements of mammographic percent density and circulating levels of estradiol, sex-hormone binding globulin (SHBG), follicle stimulating hormone (FSH), prolactin, C-terminal cross-link telopeptide, IGF-I, and IGF binding protein-3. RESULTS: Median age and time since last menses were 52 years and 15 months, respectively. Median body mass index was 24.1 kg/m(2). After adjusting for age and body mass index, estradiol was the only biomarker significantly correlated with mammographic density (r = 0.17; P = 0.04). Women with normal body mass index had higher mammographic density (P < 0.001), higher SHBG (P < 0.0001), higher FSH (P = 0.002) and lower estradiol levels (P = 0.01) than those who were overweight. Women who had previous biopsies for benign breast disease had a higher mammographic density (P = 0.006). CONCLUSIONS: In these recently postmenopausal women, mammographic percent density is directly associated with circulating estradiol levels. Our results provide further support to the role of circulating hormones in breast cancer risk.
机译：背景：内源性激素和胰岛素样生长因子（IGF）在乳腺癌的发展中起着核心作用。乳房X光检查密度是重要的乳腺癌危险因素，已与绝经前妇女的这些生物标志物相关联。这项研究的目的是评估绝经后妇女循环激素，与乳腺癌风险相关的临床特征与乳房X线照片密度之间的关系。受试者和方法：该研究纳入了226名绝经后妇女参加临床预防试验。我们进行了乳房X光检查的密度百分比和雌二醇，性激素结合球蛋白（SHBG），卵泡刺激素（FSH），催乳素，C末端交联端粒肽，IGF-I和IGF结合蛋白3循环水平的基线测量。 。结果：自上次月经以来的中位年龄和时间分别为52岁和15个月。中位数体重指数为24.1 kg / m（2）。在调整了年龄和体重指数之后，雌二醇是唯一与乳房X线照片密度显着相关的生物标志物（r = 0.17; P = 0.04）。体重指数正常的女性与超重女性相比，乳腺钼靶密度（P <0.001），SHBG（P <0.0001），FSH（P = 0.002）和雌二醇水平（P = 0.01）高。先前进行过良性乳腺活检的妇女的乳房X线照片密度较高（P = 0.006）。结论：在这些最近绝经后的妇女中，乳房X光检查的密度百分比与循环中的雌二醇水平直接相关。我们的结果为循环激素在乳腺癌风险中的作用提供了进一步的支持。

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