Bio-antimutagenic and microbicidal activities of 1-(2-oxocyclopentyliden)-3-oxadecane and the derivatives against mutagenic Escherichia coli WP2 B/r trp

KATSUKI TAKAI; ATSUSHI NAKAMURA; KENJI SHIBUTANI; RYOZO IRIYE

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Bio-antimutagenic and microbicidal activities of 1-(2-oxocyclopentyliden)-3-oxadecane and the derivatives against mutagenic Escherichia coli WP2 B/r trp

机译：1-（2-氧代环戊烯基）-3-氧杂十二烷及其衍生物对诱变性大肠杆菌WP2 B / r trp的生物抗诱变和杀微生物活性

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Since 1-(2-oxocyclopentyliden)-2-alkanols (1) showed enhanced bio-antimutagenic activity against UV-induced mutagenic Escherichia coli WP2 B/r trp, 1-(2-oxocyclopentyliden)-3-oxa-and 3-thiaalkanes (4 and 7) and 10-(2-oxocyclopentyliden)-8-oxadecanol(5) were synthesized, and their bio-antimutagenic and bactericidal activity were measured. 10-(2-Oxocyclopentyliden)-8-oxadecanol (5) showed weak activity (AD_(50), 95.5 #mu# g/ml), while 1-(2-oxocyclopentyliden)-3-oxanonane (4a) and 1-(2-oxocyclopentylidene)-3-thianonane (7) showed bactericidal activity (ID_(50), 7.5 and 11.0 #mu# g/ml, respectively).

机译：由于1-（2-氧代环戊基）-2-烷醇（1）对紫外线诱变的大肠杆菌WP2 B / r trp表现出增强的生物抗诱变活性，因此1-（2-氧代环戊基）-3-氧杂-和3-硫代烷烃合成了（4和7）和10-（2-氧代环戊基）-8-氧杂醇（5），并测定了它们的生物抗诱变和杀菌活性。 10-（2-Oxocyclopentyliden）-8-oxadecanol（5）表现出较弱的活性（AD_（50），95.5＃mu＃g / ml），而1-（2-oxocyclopentyliden）-3-oxanonane（4a）和1- （2-氧代环戊叉基）-3-噻喃酮（7）显示出杀菌活性（分别为ID_（50），7.5和11.0μμg/ ml）。

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《Biocontrol Science》 |2002年第2期|共4页
作者
KATSUKI TAKAI; ATSUSHI NAKAMURA; KENJI SHIBUTANI; RYOZO IRIYE;
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正文语种 eng
中图分类临床医学;
关键词
E. coli; bio-antimutagen; bactericidal activity; 2-oxocyclipentylidene;

机译：大肠杆菌;生物抗诱变剂;杀菌活性;2-氧代环戊二烯;

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1. Bio-antimutagenic and microbicidal activities of 1-(2-oxocyclopentyliden)-3-oxadecane and the derivatives against mutagenic Escherichia coli WP2 B/r trp [J] . KATSUKI TAKAI, ATSUSHI NAKAMURA, KENJI SHIBUTANI, Biocontrol Science . 2002,第2期

机译：1-（2-氧代环戊烯基）-3-氧杂十二烷及其衍生物对诱变性大肠杆菌WP2 B / r trp的生物抗诱变和杀微生物活性
2. Mutagenicity of carbon tetrachloride and chloroform in Salmonella typhimurium TA98, TA100, TA1535, and TA1537, and Escherichia coli WP2uvrA/pKM101 and WP2/pKM101, using a gas exposure method. [J] . Araki A, Kamigaito N, Sasaki T, Environmental and molecular mutagenesis. . 2004,第2期

机译：使用气体暴露方法，鼠伤寒沙门氏菌TA98，TA100，TA1535和TA1537以及大肠杆菌WP2uvrA / pKM101和WP2 / pKM101中四氯化碳和氯仿的致突变性。
3. Mutagenicity of 80 chemicals in Escherichia coli tester strains IC203, deficient in OxyR, and its oxyR(+) parent WP2 uvrA/pKM101: detection of 31 oxidative mutagens. [J] . Martinez A, Urios A, Blanco M Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2000,第1期

机译：大肠杆菌测试仪菌株IC203中缺乏OxyR及其oxyR（+）亲本WP2 uvrA / pKM101的80种化学物质的致突变性：检测31种氧化诱变剂。
4. Mutagenic Research on Ciliary Neurotrophic Factor (CNTF) in Escherichia coli After Heavy Ions Irradiation [C] . Xiaodong Jin, Qingfeng Wu, Xinguo Liu, International conference on applied biotechnology . 2014

机译：重离子辐照后大肠杆菌中睫状神经营养因子的诱变研究
5. Regulatory mechanism of the tryptophan operon in Escherichia coli: Possible interaction between trpR and trpS gene products [D] . Ito, Koreaki -1

机译：色氨酸操纵子在大肠杆菌中的调节机制：trpR和trpS基因产物之间可能的相互作用。
6. DNA Synthesis and Viability of a mutT Derivative of Escherichia coli WP2 under Conditions of Amino Acid Starvation and Relation to Stationary-Phase (Adaptive) Mutation [O] . Bryn A. Bridges, Sharon Ereira 1998

机译：氨基酸饥饿条件下大肠杆菌WP2 mutT衍生物的DNA合成和活力及其与固定相（自适应）突变的关系
7. Bio-antimutagenic and Microbicidal Activities of 1-(2-Oxocyclopentyliden)-3-Oxadecane and the Derivatives against Mutagenic Escherichia coil WP2 B/r trp. [O] . KATSUKI TAKAI, ATSUSHI NAKAMURA, KENJI SHIBUTANI, 2002

机译：生物 - 抗型和杀微生物活性为1-（2-氧杂碳键烯酮）-3-氧代癸烷和抗诱变大肠杆菌卷线WP2 B / R TRP的衍生物。
8. Salmonella/Mammalian-Microsome Plate Incorp. Mutagenicity Assay & Escherichia Coli WP2 UVRA Reverse Mutation Assay w/Confirmaroty Assay of DC-2-7952 w/Cover Letter Dated 04/20/1994 [R] . 1994

机译：沙门氏菌/哺乳动物 - 微粒体板合并。致突变性测定和大肠杆菌大肠杆菌Wp2 UVRa反向突变测定，具有DC-2-7952的确认测定，附封信函日期04/20/1994

Bio-antimutagenic and microbicidal activities of 1-(2-oxocyclopentyliden)-3-oxadecane and the derivatives against mutagenic Escherichia coli WP2 B/r trp

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