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首页> 外文期刊>Biomedical Engineering: Applications, Basis and Communications >PORCINE SMALL INTESTINAL SUBMUCOSA REDUCES THE INFLAMMATORY REACTION OF POLY(LACTIDE-CO-GLYCOLIDE) FILMS
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PORCINE SMALL INTESTINAL SUBMUCOSA REDUCES THE INFLAMMATORY REACTION OF POLY(LACTIDE-CO-GLYCOLIDE) FILMS

机译：猪小肠粘膜下层减少了聚（丙交酯-共-乙交酯）膜的发炎反应

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摘要

Poly(lactide-co-glycolide) (PLGA), a well-known synthetic polymer comprised of PLA and PGA, is used commonly as a scaffold for soft and hard tissue engineering purposes; however, the appropriate strategies for reducing its host tissue inflammatory response remain obscure. Porcine small intestinal submucosa (SIS) has been applied as a natural, biodegradable matrix for dressing materials, tendon graft substitutes and scaffolds. We hypothesized that the host tissue reaction of PLGA might occur but could be reduced by impregnating SIS into PLGA. We manufactured PLGA/ SIS hybrid films with 0,10, 20, 40 and 80 wt.% SIS of PLGA. The inflammatory potential of PLGA was evaluated using mRNA expression of TNF-α, IL-1β and IL-6 in the surrounding tissue of implanted scaffolds. The response of sub-cutaneously implanted PLGA/SIS films were compared to PLGA film; the local inflammatory response was observed by histology. PLGA/SIS films, especially PLGA/SIS films containing 20, 40 and 80 wt.% SIS, elicited a significantly lower expression of IL-1β, TNF-α and IL-6 than PLGA film. PLGA/SIS films demonstrated a favorable tissue response profile compared to PLGA film, with significant less inflammation and fibrous capsule formation as below only 20 wt.% of PLGA/SIS film during implantation. This study demonstrates reduced inflammatory response of PLGA by different amounts of SIS and PLGA/SIS scaffolds being used for tissue engineering constructs.
机译：聚乳酸-乙交酯共聚物（PLGA）是由PLA和PGA组成的众所周知的合成聚合物，通常用作软组织和硬组织工程学的支架。然而，减少其宿主组织炎症反应的适当策略仍然不清楚。猪小肠粘膜下层（SIS）已被用作敷料，腱移植替代物和支架的天然，可生物降解的基质。我们假设PLGA的宿主组织反应可能发生，但可以通过将SIS浸入PLGA中来减轻。我们生产的PLGA / SIS杂化膜的SIS含量为0、10、20、40和80重量％。使用植入支架周围组织中TNF-α，IL-1β和IL-6的mRNA表达来评估PLGA的炎性潜力。将皮下植入的PLGA / SIS膜与PLGA膜的反应进行了比较。通过组织学观察到局部炎症反应。 PLGA / SIS膜，特别是包含20、40和80 wt。％SIS的PLGA / SIS膜，引起IL-1β，TNF-α和IL-6的表达明显低于PLGA膜。与PLGA膜相比，PLGA / SIS膜表现出良好的组织反应特性，并且在植入过程中炎症和纤维囊的形成明显减少，因为PLGA / SIS膜的含量仅低于20％（重量）。这项研究表明通过用于组织工程构建体的不同量的SIS和PLGA / SIS支架减少了PLGA的炎症反应。

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