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首页> 外文期刊>Annual Review of Pharmacology and Toxicology >The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes.
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The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes.

机译：Gbetagamma亚基在GPCR信号复合物的组织，组装和功能中的作用。

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The role of Gbetagamma subunits in cellular signaling has become well established in the past 20 years. Not only do they regulate effectors once thought to be the sole targets of Galpha subunits, but it has become clear that they also have a unique set of binding partners and regulate signaling pathways that are not always localized to the plasma membrane. However, this may be only the beginning of the story. Gbetagamma subunits interact with G protein-coupled receptors, Galpha subunits, and several different effector molecules during assembly and trafficking of receptor-based signaling complexes and not simply in response to ligand stimulation at sites of receptor cellular activity. Gbetagamma assembly itself seems to be tightly regulated via the action of molecular chaperones and in turn may serve a similar role in the assembly of specific signaling complexes. We propose that specific Gbetagamma subunits have a broader role in controlling the architecture, assembly, and activity of cellular signalingpathways.
机译：在过去的20年中，已经很好地确定了Gbetagamma亚基在细胞信号传导中的作用。它们不仅调节曾经被认为是Galpha亚基的唯一靶标的效应子，而且很明显，它们也具有独特的结合伴侣，并调节并不总是局限于质膜的信号传导途径。但是，这可能仅仅是故事的开始。 Gbetagamma亚基与G蛋白偶联受体，Galpha亚基和几种不同的效应分子在基于受体的信号复合物的组装和运输过程中相互作用，而不仅仅是响应受体细胞活性部位的配体刺激。 Gbetagamma组装本身似乎受到分子伴侣分子的作用严格调控，进而可能在特定信号复合物的组装中起类似的作用。我们建议特定的Gbetagamma亚基在控制细胞信号通路的体系结构，装配和活性中具有更广泛的作用。

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