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首页> 外文期刊>Biomedical Research >The reciprocal relationship between heme oxygenase and nitric oxide syn-thase in the organs of lipopolysaccharide-treated rodents
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The reciprocal relationship between heme oxygenase and nitric oxide syn-thase in the organs of lipopolysaccharide-treated rodents

机译：脂多糖处理的啮齿动物器官中血红素加氧酶和一氧化氮合酶之间的相互关系

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摘要

The production of nitric oxide (NO) by inducible NO synthase (NOS) and carbon monoxide (CO)by inducible heme oxygenase (HO) contributes greatly to endotoxemia. Reciprocal relationshipshave been proposed between the NO/NOS and CO/HO systems. However, the interaction betweenthese systems during endotoxemia is unclear, and it is unknown whether the interactive behaviordiffers among organs. Using endotoxic rats, we studied the effects of the inducible NOS (iNOS)inhibitor L-canavanine (CAN), and the HO inhibitor zinc protoporphyrin (ZPP) on gene expres-sion and protein levels of iNOS, endothelial NOS (eNOS), inducible HO (HO-1), and constitutiveHO (HO-2) in the brain, lung, heart, liver and kidney tissue. Intravenous injection of LPS signifi-cantly increased iNOS and HO-1 gene expression in all organs. The effects of LPS on eNOS geneexpression differed among organs, with increased expression in the liver and kidney, and nochange in the lung, brain and heart. ZPP administration down-regulated the LPS-induced increasein HO-1 expression and produced a further increase in iNOS expression in all organs. These datasuggest that the CO/HO system modifies the NO/NOS system in endotoxic organs, and that therewere only minor organ-specific behaviors in terms of the relationship between these systems inthe organs examined.
机译：诱导型血红素加氧酶（HO）产生的一氧化氮合酶（NOS）产生一氧化氮（NO）和一氧化碳（CO）极大地促进了内毒素血症。在NO / NOS和CO / HO系统之间已经提出了相互关系。然而，内毒素血症期间这些系统之间的相互作用尚不清楚，并且相互作用行为是否在器官之间有所区别还未知。我们使用内毒素大鼠研究了诱导型NOS（iNOS）抑制剂L-canavanine（CAN）和HO抑制剂锌原卟啉（ZPP）对iNOS，内皮型NOS（eNOS）的基因表达和蛋白水平的影响脑，肺，心脏，肝和肾组织中的HO（HO-1）和本构HO（HO-2）。静脉内注射LPS可显着增加所有器官中的iNOS和HO-1基因表达。 LPS对eNOS基因表达的影响在器官之间有所不同，在肝脏和肾脏中表达增加，而在肺，脑和心脏中没有变化。 ZPP给药下调LPS诱导的HO-1表达增加，并在所有器官中iNOS表达进一步增加。这些数据表明，CO / HO系统修饰了内毒素器官中的NO / NOS系统，并且就这些器官中被检查的系统之间的关系而言，仅存在次要的器官特异性行为。

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