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首页> 外文期刊>Brain research >Effect of SNP at position 40237 in exon 7 of the TPH2 gene on susceptibility to suicide.
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Effect of SNP at position 40237 in exon 7 of the TPH2 gene on susceptibility to suicide.

机译：TPH2基因第7外显子40237位的SNP对自杀敏感性的影响。

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OBJECTIVE: The novel tryptophan hydroxylase isoform (TPH2), being the rate-limiting enzyme in the biosynthesis of serotonin, has many biological functions and plays an important role as candidate gene in several psychiatric disorders. Here, an A-G single nucleotide polymorphism (SNP) at the position 40237 relative to 5'-end of TPH2 gene was selected for the association with suicide behavior. METHODS: The study population consisted of 102 MD patients with suicide behavior as attempters and 123 MD patients without suicide behavior as non-attempters. The TPH2 SNP was determined by sequencing on an ABI 3700 automated DNA sequencer. RESULTS: The A allele was significantly less frequent in attempters than in non-attempters (p=0.0067). Individuals with the A/A genotype showed a significantly lower risk of suicide behavior than those with the A/G or G/G genotype (OR=0.35). CONCLUSIONS: Our findings suggest that the A-G polymorphism of TPH2 may confer susceptibility to suicide behavior in MD patients.
机译：目的：新型色氨酸羟化酶同工酶（TPH2）是5-羟色胺生物合成中的限速酶，具有多种生物学功能，并在多种精神疾病中起候选基因的重要作用。在这里，相对于TPH2基因的5'-末端在40237位的A-G单核苷酸多态性（SNP）被选择用于自杀行为。方法：研究人群包括102名尝试自杀的MD患者和123名未尝试自杀的MD患者。通过在ABI 3700自动DNA测序仪上测序来确定TPH2 SNP。结果：尝试者中的A等位基因频率显着低于未尝试者（p = 0.0067）。 A / A基因型个体的自杀行为风险显着低于A / G或G / G基因型个体（OR = 0.35）。结论：我们的发现表明，TPH2的A-G多态性可能使MD患者的自杀行为易感。

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