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首页> 外文期刊>Inflammatory bowel diseases >Homing imprinting and immunomodulation in the gut: role of dendritic cells and retinoids.
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Homing imprinting and immunomodulation in the gut: role of dendritic cells and retinoids.

机译：肠道中的归巢印迹和免疫调节：树突状细胞和类维生素A的作用。

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摘要

Lymphocyte migration is at the heart of chronic inflammatory ailments, including inflammatory bowel disease (IBD). Whereas naive lymphocytes migrate to all secondary lymphoid organs, they are mostly excluded from nonlymphoid peripheral tissues. Upon activation, lymphocytes change their pattern of adhesion receptors and acquire the capacity to migrate to extralymphoid tissues. Antigen-experienced T cells are subdivided into different subsets based on their expression of homing receptors that favor their accumulation in specific tissues, such as the skin and the gut mucosa. B cells and antibody-secreting cells (ASC) also show tissue-tropism, which is somewhat correlated with the class of immunoglobulin that they produce. In fact, IgA-ASC are located in mucosal tissues, where they produce IgA, the main class of antibodies found in secretions. Although IgA-ASC are usually considered as a homogeneous pool of cells, those located in the small bowel have some unique migratory characteristics, suggesting that they are generated under different conditions as compared to IgA-ASC in other mucosal compartments. Foxp3(+) regulatory T cells (T(REG)) can also exhibit tissue-specific migratory potential and recent evidence suggests that T(REG) can be imprinted with gut-specific homing. Moreover, foxp3(+) T(REG) are enriched in the small bowel lamina propria, where they can be generated locally. The present review addresses our current understanding of how tissue-specific homing is acquired and modulated on T cells, B cells, and ASC, with a special emphasis on the intestinal mucosa. Harnessing these mechanisms could offer novel, effective, and more specific therapeutic strategies in IBD.
机译：淋巴细胞迁移是包括炎症性肠病（IBD）在内的慢性炎症的核心。尽管幼稚的淋巴细胞迁移到所有次生淋巴器官，但它们大多被非淋巴性外周组织所排斥。激活后，淋巴细胞会改变其粘附受体的模式，并具有迁移至淋巴外组织的能力。抗原经历过的T细胞根据归巢受体的表达而细分为不同的亚组，这些受体有利于它们在特定组织（如皮肤和肠粘膜）中的积累。 B细胞和抗体分泌细胞（ASC）也显示出组织趋向性，这与它们产生的免疫球蛋白的种类有些相关。实际上，IgA-ASC位于粘膜组织中，在那里它们产生IgA，这是分泌物中发现的主要抗体类别。尽管通常认为IgA-ASC是细胞的均质池，但是位于小肠中的细胞具有某些独特的迁移特性，这表明与其他粘膜区室中的IgA-ASC相比，它们是在不同条件下产生的。 Foxp3（+）调节性T细胞（T（REG））也可以表现出组织特异性的迁移潜能，最近的证据表明T（REG）可以被肠道特异性归巢。此外，foxp3（+）T（REG）富集在小肠固有层中，它们可以在当地产生。本综述阐述了我们目前对如何在T细胞，B细胞和ASC上获取和调节组织特异性归巢的理解，其中特别强调肠道粘膜。利用这些机制可以在IBD中提供新颖，有效和更具体的治疗策略。

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