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首页> 外文期刊>British Journal of Haematology >Longitudinal analysis of antibody response to immunization in paediatric survivors after allogeneic haematopoietic stem cell transplantation.
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Longitudinal analysis of antibody response to immunization in paediatric survivors after allogeneic haematopoietic stem cell transplantation.

机译：异基因造血干细胞移植后小儿幸存者对抗体免疫反应的纵向分析。

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摘要

The long-term antibody responses to re-immunization in recipients of allogeneic haematopoietic stem cell transplantation (allo-HSCT) have not been well studied. We prospectively and longitudinally evaluated the antibody responses to eight vaccine antigens (diphtheria, tetanus, pertussis, measles, mumps, rubella, hepatitis B, and poliovirus) and assessed the factors associated with negative titres in 210 allo-HSCT recipients at St. Jude Children's Research Hospital. Antibody responses lasting for more than 5 years after immunization were observed in most patients for tetanus (95.7%), rubella (92.3%), poliovirus (97.9%), and, in diphtheria-tetanus-acellular pertussis (DTaP) recipients, diphtheria (100%). However, responses to pertussis (25.0%), measles (66.7%), mumps (61.5%), hepatitis B (72.9%), and diphtheria in tetanus-diphtheria (Td) recipients (48.6%) were less favourable, with either only transient antibody responses or persistently negative titres. Factors associated with vaccine failure were older age at immunization; lower CD3, CD4 or CD19 counts; higher IgM concentrations; positive recipient cytomegalovirus serology; negative titres before immunization; acute or chronic graft-versus-host disease; and radiation during preconditioning. These response patterns and clinical factors can be used to formulate re-immunization and monitoring strategies. Patients at risk for vaccine failure should have long-term follow-up; those with loss of antibody response or no seroconversion should receive booster immunizations.
机译：尚未对异基因造血干细胞移植（allo-HSCT）接受者对重新免疫的长期抗体应答进行研究。我们从前瞻性和纵向评估了对八种疫苗抗原（白喉，破伤风，百日咳，麻疹，腮腺炎，风疹，乙型肝炎和脊髓灰质炎病毒）的抗体应答，并评估了圣裘德儿童医院210名同种异体造血干细胞移植受体阴性滴度的相关因素。研究医院。在大多数患者中，针对破伤风（95.7％），风疹（92.3％），脊髓灰质炎病毒（97.9％）以及白喉-破伤风-无细胞百日咳（DTaP）受体的白喉患者，抗体反应持续超过5年。 100％）。然而，破伤风-白喉（Td）接受者对百日咳（25.0％），麻疹（66.7％），腮腺炎（61.5％），乙型肝炎（72.9％）和白喉的反应（48.6％）较不受欢迎，两者中只有一种短暂的抗体反应或持续的负滴度。与疫苗失败有关的因素是免疫时年龄较大。降低CD3，CD4或CD19计数; IgM浓度较高;接受者巨细胞病毒血清学阳性;免疫前滴度为负;急性或慢性移植物抗宿主病;预处理期间的辐射和辐射。这些反应模式和临床因素可用于制定重新免疫和监测策略。有疫苗失败风险的患者应进行长期随访;那些没有抗体反应或没有血清转换的人应接受加强免疫。

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