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首页> 外文期刊>Integrative cancer therapies >Elimination of deleterious effects of DMBA-induced skin carcinogenesis in mice by Syzygium cumini seed extract.
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Elimination of deleterious effects of DMBA-induced skin carcinogenesis in mice by Syzygium cumini seed extract.

机译：孜然籽提取物消除了DMBA诱导的小鼠皮肤癌变的有害作用。

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The inhibition of tumor incidence by hydro-alcoholic extract of S.cumini seed was evaluated in mice on two stage process of skin carcinogenesis induced by single application of 7, 12-dimethyl benz(a)anthracene (100 microg/100microl of acetone), and 2 weeks later promoted by repeated application of croton oil (1% acetone/thrice in a week) till the end of the experiment (i.e. 16 weeks). Oral administration of extract at a dose of 250mg/kg b.wt./day at the peri-initiational stage (i.e. 7 days before and 7 days after DMBA application), promotional stage (i.e. from the time of croton oil application) and at both the stages (i.e. 7 days prior to DMBA application & continued till the end of experiment) to the mice, recorded a significant reduction in tumor incidence to 37.5, 50 & 25% respectively in comparison to the carcinogen treated control, where tumor incidence was found as 100%. Tumor yield and Tumor burden were also significantly reduced by SCE. Similarly, the cumulative number of papillomas after 16 weeks was 68 in the control group, which was reduced to 15, 21 & 8 in the animals treated with the SCE continuously at peri-, post- and peri- & post- initiation stage respectively. A significant impairment was noticed in the levels of reduced glutathione, superoxide dismutase, catalase & protein and enhancement in LPO in liver and skin of carcinogen treated control mice as compared with vehicle treated mice. All such parameters were returned to near normal value by administration of SCE to DMBA treated mice. These results suggest a possible chemopreventive property of S.cumini against DMBA induced skin carcinogenesis in mice.
机译：在小鼠中，通过一次施用7、12-二甲基苯并（a）蒽（100微克/ 100微升丙酮）诱导的皮肤致癌的两个阶段，在小鼠中评估了葡萄球菌种子的乙醇提取物对肿瘤发生的抑制作用， 2周后，通过重复使用巴豆油（一周内1％丙酮/三次）促进直至实验结束（即16周）。在初生阶段（即DMBA施用前7天和7天后），促进阶段（即从巴豆油施用之时）和口服时，以250mg / kg b.wt./day的剂量口服提取物与致癌物治疗的对照组相比，小鼠的两个阶段（即在DMBA施用前7天并持续到实验结束）的两个阶段均记录到，与致癌物对照相比，肿瘤发生率分别显着降低至37.5％，50％和25％。发现为100％。 SCE还显着降低了肿瘤的产量和肿瘤的负担。同样，对照组在16周后的乳头状瘤累积数量为68，在开始后的围产期，围产期和围产期及围产期后，分别用SCE处理的动物分别减少到15、21和8。与赋形剂处理的小鼠相比，在致癌物处理的对照小鼠的肝脏和皮肤中，谷胱甘肽，超氧化物歧化酶，过氧化氢酶和蛋白质的减少水平以及LPO的增强存在明显的损害。通过对DMBA治疗的小鼠施用SCE使所有这些参数恢复到接近正常值。这些结果表明S.cumini对DMBA诱导的小鼠皮肤致癌作用可能具有化学预防作用。

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