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首页> 外文期刊>Injury >Antimicrobial peptides: review of their application in musculoskeletal infections.
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Antimicrobial peptides: review of their application in musculoskeletal infections.

机译：抗菌肽：在肌肉骨骼感染中的应用综述。

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Antimicrobial resistance is expected to increase the burden of osteomyelitis drastically. The rise in resistant bacterial strains is driving researchers to find new treatment options. As a potential new antibiotic class, antimicrobial peptides (AMPs) combine several attractive intrinsic properties. Their minimal propensity for inducing antimicrobial resistance could be of particular clinical significance. AMPs act as an essential part of the innate immune system and have been identified in virtually all forms of life. These short, positively charged peptides have a combined pore-forming and intracellular killing effect on a broad range of microorganisms. Their reported spectrum of action includes resistant bacterial strains, viruses, and fungi. Moreover, immunomodulating, antitumoric, and angiogenic mechanisms have been reported. We have designed degradable and nondegradable drug-release systems for local treatment with AMPs. In animal models of osteomyelitis, these systems reduced bone infection caused by both resistant and nonresistant strains. The systemic application of several peptides for experimental detection and treatment of bone and soft-tissue infection is also discussed in this review. Radioactive-labeled peptides have accurately discriminated sterile inflammation from active infection in imaging studies. Successful preclinical studies of AMPs indicate that clinical evaluation of these powerful antibiotic agents is in order.
机译：抗菌药物的耐药性有望大大增加骨髓炎的负担。抗药性菌株的增加促使研究人员寻找新的治疗方案。作为一种潜在的新型抗生素，抗菌肽（AMP）结合了多种吸引人的内在特性。它们诱导抗菌素耐药性的最小倾向可能具有特殊的临床意义。 AMPs是先天免疫系统的重要组成部分，实际上已经在所有形式的生命中被发现。这些短的带正电荷的肽对多种微生物具有共同的造孔和细胞内杀伤作用。他们报道的作用范围包括抗药性菌株，病毒和真菌。而且，已经报道了免疫调节，抗肿瘤和血管生成机制。我们设计了可降解和不可降解的药物释放系统，用于使用AMP进行局部治疗。在骨髓炎的动物模型中，这些系统减少了由耐药菌和非耐药菌引起的骨感染。本文还讨论了几种肽在骨和软组织感染的实验检测和治疗中的全身应用。在影像学研究中，放射性标记的肽已准确地将无菌炎症与主动感染区分开。 AMP的成功临床前研究表明，对这些强大的抗生素药物进行临床评估是有必要的。

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