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首页> 外文期刊>Brain research. Brain research protocols >Differences in the magnitude of long-term potentiation produced by theta burst and high frequency stimulation protocols matched in stimulus number.
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Differences in the magnitude of long-term potentiation produced by theta burst and high frequency stimulation protocols matched in stimulus number.

机译：θ爆裂和高频刺激方案产生的长期增强幅度的差异与刺激次数相匹配。

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摘要

Theta-burst stimulation (TBS: four pulses at 100 Hz repeated with 200 ms inter-burst-intervals) and another commonly used high-frequency stimulation protocol (HFS: 1 s burst of equally spaced pulses at 100 Hz) were compared for the magnitude of LTP produced in rat hippocampal slices. The total number of pulses applied during tetanus (TET) was either 40, 100, 200, or 300. In a conventional analysis of the last 10 min of the post-TET period, a two-way ANOVA revealed no difference either in LTP of the field excitatory post-synaptic potential (fEPSP) between TBS and HFS or differences across pulse number at 40, 100, or 200 pulses. At 300 pulses, there was a significant main effect by pulse number but not by protocol. A linear regression analysis showed that stimulation protocol accounted for only about 10% of the change in magnitude while pulse number contributed to 30% of the change. However, when an extended analysis of the same data was performed across the entire post-TET period with a repeated-measureANOVA, a small but persistent increase in TBS over HFS at 200 pulses was significant. A difference between TBS and HFS at 300 pulses that occurred only during the early phase of LTP was also significant. These results suggest that, over a range of stimuli, the number of pulses in an induction protocol, rather than the pattern of stimulation, determines the magnitude of late phase LTP, while TBS produces greater potentiation than HFS in the early phase of LTP with higher TET number.
机译：比较了Theta-burst刺激（TBS：100 Hz的四个脉冲，脉冲间隔为200 ms重复）和另一种常用的高频刺激方案（HFS：100 Hz的等间隔脉冲的1 s猝发）的幅度大鼠海马切片中产生的LTP的百分比。破伤风（TET）期间施加的脉冲总数为40、100、200或300。在对TET后阶段最后10​​分钟的常规分析中，双向方差分析表明LTP的LTP均无差异TBS和HFS之间的场兴奋性突触后电位（fEPSP）或40、100或200个脉冲时的脉冲数差异。在300个脉冲时，主要的影响是脉冲数，而不是协议。线性回归分析表明，刺激方案仅占幅度变化的10％，而脉冲数占变化的30％。但是，当在整个TET后期间使用重复测量方差分析进行相同数据的扩展分析时，在200个脉冲下，TBS相对于HFS的微小但持续的增加是显着的。仅在LTP的早期阶段发生的300个脉冲的TBS和HFS之间的差异也很显着。这些结果表明，在一定范围的刺激下，诱导方案中的脉冲数而不是刺激方式决定了后期LTP的强度，而在LTP早期，TBS产生的增强作用要强于HFS，而在LTP的作用下具有更高的增强作用。 TET号。

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