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首页> 外文期刊>Biomedical Research >Effects of a dopamine receptor agonist and atropine sulfate on absorption ofvalproic acid in rats
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Effects of a dopamine receptor agonist and atropine sulfate on absorption ofvalproic acid in rats

机译：多巴胺受体激动剂和硫酸阿托品对大鼠丙戊酸吸收的影响

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摘要

The aim of this study is to determine whether pramipexole hydrochloride hydrate (PHH) and atro-pine sulfate affect valproic acid (VPA) pharmacokinetics and to evaluate how plasma VPA con-centrations are altered by different PHH administration routes. The following studies wereconducted on rats: 1) changes in plasma VPA concentration after simultaneous oral administration(PO) of PHH and VPA-Na; 2) effects of intraperitoneal administration (IP) of PHH on plasmaVPA concentration after VPA-Na PO; 3) effects of PHH PO on plasma VPA concentration afterintravenous administration (IV) of VPA-Na; and 4) changes in plasma VPA concentration after si-multaneous PO of atropine sulfate and VPA-Na. Atropine sulfate PO significantly decreased thearea under the concentration-time curve up to 3 h (AUCO-3, the total amount of drug plasma con-centration) of VPA, suggesting that atropine sulfate decreases VPA-Na absorption probably due toreduced gastrointestinal motility by its anticholinergic action. Similarly, by PHH PO or IP, VPAAUCO-3 was significantly decreased. However, in cases of VPA-Na IV, all VPA parameters wereunchanged by PHH PO. These results indicate that the PHH inhibitory effect may be caused inthe absorption phase of VPA by pharmacological action of PHH, and thus PHH decreases VPA-Nabioavailability.
机译：这项研究的目的是确定盐酸普拉克索水合物（PHH）和硫酸阿托品是否会影响丙戊酸（VPA）的药代动力学，并评估通过不同的PHH给药途径如何改变血浆VPA浓度。对大鼠进行了以下研究：1）同时口服PHH和VPA-Na后血浆VPA浓度的变化; 2）腹腔注射PHH对VPA-Na PO后血浆VPA浓度的影响; 3）静脉注射VPA-Na后，PHH PO对血浆VPA浓度的影响; 4）硫酸阿托品和VPA-Na同时进行PO后血浆VPA浓度变化。硫酸阿托品PO在浓度-时间曲线上可显着降低VPA的浓度-时间曲线（AUCO-3，药物血浆总浓度），这表明硫酸阿托品PO降低了VPA-Na吸收，这可能是由于其胃肠道蠕动降低所致。抗胆碱作用。同样，通过PHH PO或IP，VPAAUCO-3明显降低。但是，对于VPA-Na IV，PHH PO不会更改所有VPA参数。这些结果表明，PHH的抑制作用可能是由于PHH的药理作用在VPA的吸收阶段引起的，因此PHH降低了VPA-生物利用度。

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