Quantitative strategies to fuel the merger of discovery and hypothesis-driven shotgun proteomics

Kelli G. Kline; Greg L. Finney; Christine C. Wu

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Quantitative strategies to fuel the merger of discovery and hypothesis-driven shotgun proteomics

机译：推动发现与假设驱动shot弹枪蛋白质组学融合的定量策略

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The ultimate goal of most shotgun proteomic pipelines is the discovery of novel biomarkers to direct the develop-ment of quantitative diagnostics for the detection and treatment of disease. Differential comparisons of biologicalsamples identify candidate peptides that can serve as proxys of candidate proteins. While these discoveryapproaches are robust and fairly comprehensive, they have relatively low throughput. When merged with targetedmass spectrometry, this pipeline can fuel hypothesis-driven studies and the development of novel diagnostics andtherapeutics.

机译：大多数shot弹枪蛋白质组学的最终目标是发现新型生物标志物，以指导定量诊断方法的发展，以检测和治疗疾病。生物样品的差异比较确定了可以用作候选蛋白质代理的候选肽。尽管这些发现方法是可靠且相当全面的，但它们的吞吐量相对较低。当与目标质谱联用时，这条管道可以推动假设驱动的研究以及新型诊断学和治疗学的发展。

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《Briefings in functional genomics & proteomics》 |2009年第2期|共12页
作者
Kelli G. Kline; Greg L. Finney; Christine C. Wu;
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正文语种 eng
中图分类遗传学;
关键词
quantitative shotgun proteomics; biomarker discovery; targeted mass spectrometry; human tissue;

机译：定量shot弹蛋白质组学;生物标志物发现;靶向质谱法;人体组织;

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1. Quantitative strategies to fuel the merger of discovery and hypothesis-driven shotgun proteomics [J] . Kelli G. Kline, Greg L. Finney, Christine C. Wu Briefings in functional genomics & proteomics . 2009,第2期

机译：推动发现与假设驱动shot弹枪蛋白质组学融合的定量策略
2. Interpretation of large-scale quantitative shotgun proteomic profiles for biomarker discovery. [J] . Isserlin R, Emili A Current Opinion in Molecular Therapeutics . 2008,第3期

机译：解释用于生物标记物发现的大规模定量shot弹枪蛋白质组学概况。
3. Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: methodology, advantages, strategy, and prospects. [J] . Ohtsuki S, Uchida Y, Kubo Y, Journal of pharmaceutical sciences. . 2011,第9期

机译：基于绝对蛋白质组学的定量靶向ADME研究作为药物发现和开发的新途径：方法，优势，策略和前景。
4. Investigation of hepatic insulin resistance using an integrated shotgun/targeted quantitative proteomic strategies [C] . Yibo Wu, Eduard Sabido, Thomas Porstmann, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：用综合霰弹枪/靶向定量蛋白质组学策略调查肝胰岛素抵抗
5. Feature detection using high-resolution mass spectrometry: Software and applications for shotgun proteomics. [D] . Hoopmann, Michael Raymond. 2009

机译：使用高分辨率质谱的特征检测：shot弹枪蛋白质组学的软件和应用程序。
6. Quantitative strategies to fuel the merger of discovery and hypothesis-driven shotgun proteomics [O] . Kelli G. Kline, Greg L. Finney, Christine C. Wu -1

机译：促进发现与假设驱动shot弹枪蛋白质组学融合的定量策略
7. Quantitative strategies to fuel the merger of discovery and hypothesis-driven shotgun proteomics [O] . Kline, Kelli G., Finney, Greg L., Wu, Christine C. 2009

机译：促进发现与假设驱动shot弹枪蛋白质组学融合的定量策略
8. Quantitative Shotgun Proteomics of HD Induced Corneal Injury and Angiogenesis (Briefing Charts) [R] . Schlager, J. 2010

机译：HD诱导角膜损伤和血管生成的定量shotgun蛋白质组学（简报图）

Quantitative strategies to fuel the merger of discovery and hypothesis-driven shotgun proteomics

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