Voriconazole toxicity related to polymorphisms in CYP2C19

SuanD.; OConnorK.; BoothD.R.; LiddleC.; StewartG.J.

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Voriconazole toxicity related to polymorphisms in CYP2C19

机译：伏立康唑与CYP2C19基因多态性相关的毒性

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A 43-year-old Indian woman was admitted for investigation of visual blurring in her right eye. She had a 17-year history of relapsing Wegener's granulomatosis, which had resulted in complete loss of vision of her left eye and bilateral hearing deficits. Six months prior to her presentation, she had been recommenced on intravenous cyclo-phosphamide for relapsed pulmonary disease.

机译：一名43岁的印度妇女因调查右眼视力模糊而入院。她有17年复发韦格纳肉芽肿病的病史，这导致她的左眼视力完全丧失和双侧听力障碍。在就诊前六个月，她因复发性肺部疾病而被推荐静脉注射环磷酰胺。

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《Internal medicine journal》 |2011年第4期|共2页
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SuanD.; OConnorK.; BoothD.R.; LiddleC.; StewartG.J.;
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正文语种 eng
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1. Voriconazole toxicity related to polymorphisms in CYP2C19 [J] . SuanD., OConnorK., BoothD.R., Internal medicine journal . 2011,第4期

机译：伏立康唑与CYP2C19基因多态性相关的毒性
2. Population pharmacokinetics of voriconazole and CYP2C19 CYP2C19 polymorphisms for optimizing dosing regimens in renal transplant recipients [J] . Lin Xiao‐bin, Li Zi‐wei, Yan Miao, British Journal of Clinical Pharmacology . 2018,第7期

机译：Voriconazole的人口药代动力学和CYP2C19 CYP2C19多态性，用于优化肾移植受者的剂量治疗剂
3. Response to "Pharmacogenetics of Voriconazole: CYP2C19 but Also CYP3A4 Need to Be Genotyped" - The Role of CYP3A4 and CYP3A5 Polymorphisms in Clinical Pharmacokinetics of Voriconazole [J] . Walsh T. J., Moriyama B., Penzak S. R., Clinical Pharmacology and Therapeutics . 2017,第2期

机译：反应“伏立康唑的药物生物：CYP2C19，但也需要进行基因分型” - CYP3A4和CYP3A5多态性在Voriconazole的临床药代动力学中的作用
4. Decreased Urinary Excretion of Hydroxylated Metabolites of Voriconazole in CYP2C19 Poor Metabolizers [C] . Joo-Youn Cho, Hyang Hee Yang, Seo Hyun Yoon, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：降低CYP2C19贫困代谢物中voriconazole的羟基化代谢物的尿液排泄
5. Effect of Cytochrome P450 2C19 Genotyping and Therapeutic Drug Monitoring on Efficacy and Toxicity of Voriconazole Therapy [D] . Lee, Joseph Zhuo Lun. 2016

机译：细胞色素P450 2C19基因分型和治疗药物监测对伏立康唑治疗的疗效和毒性的影响
6. Population pharmacokinetics of voriconazole and CYP2C19 polymorphisms for optimizing dosing regimens in renal transplant recipients [O] . Xiao‐bin Lin, Zi‐wei Li, Miao Yan, 2018

机译：伏立康唑和CYP2C19基因多态性的群体药代动力学优化肾脏移植受者的给药方案
7. A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug–Drug Interactions [O] . Xia Li, Sebastian Frechen, Daniel Moj, 2019

机译：基于生理基于voriconazole的药代动力学模型，整合CYP3A4的时间依赖性抑制，CYP2C19的遗传多态性和药物 - 药物相互作用的预测

Voriconazole toxicity related to polymorphisms in CYP2C19

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