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Semen variation in a population of fertile donors: Evaluation in a French centre over a 34-year period

机译:可育供体人群精液变化:在法国中心进行的34年评估

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Although it has been suspected that there is a decrease in semen quality over time, the results reported to date remain debatable because of methodological issues. The aim of the study reported here was to investigate the evolution of semen quality over time in a population of 1114 fertile candidates for sperm donation at CECOS, Tours, between 1976 and 2009. We investigated semen volume, sperm concentration, progressive motility, vitality, percentage of normal forms and multiple abnormalities index of the first ejaculate in this population. We did not find a decline in semen volume, whereas we observed a significant decrease in total sperm count (from 443.2 million in 1976 to 300.2 million in 2009), motility (from 64% in 1976 to 49% in 2009) and vitality (from 88% to 80%). Moreover, a significant decline in the percentage of normal forms was noted between 1976 and 1997 (from 67% to 26%) with a steady rise in the multiple abnormalities index between 1998 and 2009 (from 1.19 to 1.65). This study involving a population of fertile men from a restricted area revealed various degrees of decline in semen parameters over a period of 34years. These findings will have to be compared with findings in other geographical areas.
机译:尽管人们怀疑精液质量会随着时间的流逝而下降,但由于方法问题,迄今为止报道的结果仍有争议。本研究报告的目的是调查1976年至2009年间在图尔CECOS的1114个可育精子捐赠人群中精液质量随时间的变化。我们研究了精液量,精子浓度,运动能力,活力,该人群中第一次射精的正常形式和多重异常指数的百分比。我们没有发现精液量下降,但是我们观察到精子总数(从1976年的4.432亿下降到2009年的3.002亿),活力(从1976年的64%下降到2009年的49%)和活力(从88%到80%)。此外,在1976年至1997年之间,正常形式的百分比显着下降(从67%下降到26%),而在1998年至2009年之间,多重异常指数稳步上升(从1.19上升到1.65)。这项研究涉及一个来自禁区的可育男性人群,显示在34年的时间内精液参数有不同程度的下降。这些发现必须与其他地理区域的发现进行比较。

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