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首页> 外文期刊>International journal of antimicrobial agents >Improved efficacy with nonsimultaneous administration of netilmicin and minocycline against methicillin-resistant Staphylococcus aureus in in vitro and in vivo models.
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Improved efficacy with nonsimultaneous administration of netilmicin and minocycline against methicillin-resistant Staphylococcus aureus in in vitro and in vivo models.

机译：在体外和体内模型中，同时同时施用奈替米星和米诺环素对耐甲氧西林的金黄色葡萄球菌有改善的疗效。

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The effect of combined administration of netilmicin and minocycline against methicillin-resistant Staphylococcus aureus (MRSA) was investigated by using in vitro and in vivo models. Thirty one isolates of MRSA were tested for sensitivity to netilmicin, minocycline, and combination of both by the chequer board method. We used then a dynamic in vitro system, which simulates in vivo serum kinetics, to assess the effect of various combination regimens of these antibiotics against an MRSA isolate with a fractional inhibitory concentration index of 0.25. The following dose regimens were compared: netilmicin given alone; minocycline given alone; both antibiotics given simultaneously; netilmicin followed by minocycline at 2 h; or minocycline followed by netilmicin at 2 h. Netilmicin showed a stronger activity than minocycline. On the other hand, their combination was synergistic against 19% of isolates and additive against 77% of isolates. Against one isolate only, it was indifferent, and no antagonism was observed. In the auto-simulation system, the combination of antibiotics was generally more effective than single drugs, with the regimen netilmicin followed by minocycline at 2 h showing the highest antibacterial effect. In the mouse model of pulmonary infection, the bacterial counts and histopathological findings of the lungs improved by treatment with this regimen. This regimen led also to a significantly high survival rate of mice with systemic infection compared to the other treatment regimens. Therefore, it was concluded that administration of netilmicin followed by minocycline at 2 h may be an effective combination against MRSA infection.
机译：通过使用体内和体外模型，研究了奈替米星和米诺环素联合给药对耐甲氧西林的金黄色葡萄球菌（MRSA）的作用。通过检查板方法测试了31株MRSA对奈替米星，米诺环素以及二者的组合的敏感性。然后，我们使用了动态体外系统，该系统模拟了体内血清动力学，以评估这些抗生素对分数抑制浓度指数为0.25的MRSA分离物的各种组合方案的影响。比较以下剂量方案：单独给予奈替米星;单独给予米诺环素;两种抗生素同时给予;奈替米星，接着是米诺环素2 h;或米诺环素，然后奈替米星2小时。奈替米星显示出比米诺环素更强的活性。另一方面，它们的组合对19％的分离株具有协同作用，而对77％的分离株具有协同作用。仅针对一种分离物，它是无差异的，没有观察到拮抗作用。在自动模拟系统中，抗生素的组合通常比单一药物更有效，奈替米星方案接着米诺环素方案在2 h表现出最高的抗菌作用。在这种小鼠的肺部感染模型中，通过这种方案的治疗可以改善肺部细菌计数和组织病理学发现。与其他治疗方案相比，该方案还导致全身感染小鼠的存活率显着提高。因此，得出的结论是，在2小时内给予奈替米星和米诺环素可能是对抗MRSA感染的有效组合。

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