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首页> 外文期刊>International journal of antimicrobial agents >Thioridazine treatment prevents cardiopathy in Trypanosoma cruzi infected mice
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Thioridazine treatment prevents cardiopathy in Trypanosoma cruzi infected mice

机译：硫代达嗪治疗可预防克鲁斯锥虫感染的小鼠的心脏病

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摘要

Trypanosoma cruzi trypanothione reductase is an enzyme that has been identified as a potential target for chemotherapy. Thioridazine inhibits it and prevented cardiopathy in mice infected with T cruzi Tulahuen strain. As not all T cruzi strains respond to treatment in the same way, an isolate from a chronic patient (SGO Z12) was used; parasitaemias were studied along with, survival, serology, electrocardiography, histology and cardiac beta receptor function. Parasitaemia in thioridazine (80 mg/(kg day) for 3 days) treated mice was less and lasted for a shorter period (P < 0.01), there were reduced electrocardiographic and histological alterations and significantly improved survival (80% of non-treated died). Treated mice had lower receptor affinity and higher density as a compensatory mechanism, modifying the course of T cruzi infection (SGO Z12 isolate) and preventing the consequent cardiopathy. (C) 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
机译：克氏锥虫锥虫硫醇还原酶是一种已被确定为化学疗法潜在靶点的酶。硫达达嗪可抑制它并预防T克鲁兹Tulahuen株感染小鼠的心脏疾病。由于并非所有的克氏锥虫菌株都以相同的方式对治疗产生反应，因此使用了来自慢性病患者的分离株（SGO Z12）。研究了寄生虫血症，生存率，血清学，心电图，组织学和心脏β受体功能。硫代哒嗪（80 mg /（kg·天）3天）治疗小鼠的寄生虫血症较少且持续时间较短（P <0.01），心电图和组织学改变减少，存活率显着提高（80％未治疗的患者死亡）。处理过的小鼠具有较低的受体亲和力和较高的密度，这是一种补偿机制，可以改变T克鲁兹氏菌感染的过程（SGO Z12分离株）并预防随后的心脏病。 （C）2004年Elsevier B.V.和国际化学疗法学会。版权所有。

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