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首页> 外文期刊>International clinical psychopharmacology >Evaluation of actigraphy and automated telephoned questionnaires to assess hypnotic effects in insomnia.
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Evaluation of actigraphy and automated telephoned questionnaires to assess hypnotic effects in insomnia.

机译：评估书法和自动电话调查表以评估失眠中的催眠作用。

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This study aimed to explore new methodologies in insomnia research, namely whether actigraphy was suitable to show hypnotic effects over weeks in insomnia, and to compare an automated method of questionnaire data collection with traditional methods. Thirty-eight insomniacs took part in a 5-week, double-blind, placebo-controlled study of the effects of 2 weeks of administration of temazepam 20 mg on sleep. Outcome measures were actigraphy and daily St Mary's Hospital Sleep Questionnaires (SMHSQ). Actigraphy was performed using Actiwatch (CNT) and analysed using both the automated Actiwatch sleep analysis software and non-parametric analysis of rest-activity rhythms. The questionnaires were administered as straightforward pencil-and-paper for half of the time and an automated telephoned system for the other half. The experimental paradigm allowed within-subject comparison of traditional and automated data collection, both on and off drug. Actigraphy showed a high degree of inter-subject variability but, nevertheless, some sleep variables (Fragmentation Index, Actual Sleep Time %) showed significant improvement during drug treatment, and Sleep Efficiency and Actual Sleep Time were significantly worsened during the first post-drug week. Nonparametric circadian rhythm analysis showed no significant effect. Subjective data from the SMHSQ showed significant drug effects and there was no significant difference in scores between the automated and pencil-and-paper methods; automated data collection was slightly more acceptable to patients and minimized data entry and management. Effect sizes using within-subject and between-subject comparisons were calculated for the subjective and objective measures to inform future studies
机译：这项研究旨在探讨失眠研究的新方法，即书法是否适合在失眠的数周内显示催眠作用，并将自动问卷数据收集方法与传统方法进行比较。 38名失眠症患者参加了一项为期5周，双盲，安慰剂对照的研究，研究了2周服用替马西m 20 mg对睡眠的影响。结果是书法检查和每日圣玛丽医院睡眠问卷（SMHSQ）。使用Actiwatch（CNT）进行Actigraphy，并使用自动Actiwatch睡眠分析软件和休息时间节律的非参数分析进行分析。问卷的一半时间以简单的纸笔形式进行管理，另一半时间以自动电话系统进行管理。实验范式允许对药物内部和外部的传统和自动数据收集进行受试者内部比较。书法表现出较高的受试者间变异性，但是在药物治疗期间某些睡眠变量（破碎指数，实际睡眠时间％）显示出显着改善，并且在药物治疗后的第一周内，睡眠效率和实际睡眠时间显着恶化。非参数昼夜节律分析显示无明显影响。来自SMHSQ的主观数据显示出显着的药物作用，并且自动方法和铅笔纸方法之间的得分没有显着差异。自动化的数据收集对于患者来说稍微更容易接受，并且可以最大程度地减少数据输入和管理。通过主观和客观测量计算了受试者内部和受试者之间比较的效应量，以为将来的研究提供参考

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