• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International clinical psychopharmacology >Reducing the dose of antipsychotic medications for those who had been treated with high-dose antipsychotic polypharmacy: an open study of dose reduction for chronic schizophrenia.
【24h】

Reducing the dose of antipsychotic medications for those who had been treated with high-dose antipsychotic polypharmacy: an open study of dose reduction for chronic schizophrenia.

机译：减少已接受大剂量抗精神病药多药治疗的人的抗精神病药剂量：减少慢性精神分裂症剂量的开放研究。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

SUMMARY: Antipsychotic medications are often used at higher than the recommended dose and sometimes in a combination regimen to treat schizophrenia. However, in general, high-dose therapies have been abandoned in recent clinical studies. In this study, dose reduction of antipsychotic medication was implemented for patients with chronic schizophrenia, most of whom (81%) had been treated with an antipsychotic high-dose polypharmacy regimen consisting of more than 1000 mg/day in total amount. The results show that merely reducing the amount of antipsychotic led to favourable outcome in 23 out of 41 cases (56%), with another 13 cases (32%) showing no change. Dose reduction ended in failure in only five subjects (12%). Overall, the amount as well as the number of antipsychotic medications was significantly reduced from 1984 mg to 812 mg per day (reductions of 59% and from 3.6 to 2.2, respectively; both P<0.0001). The Global Assessment of Functioning scale improved from 30.6 to 37.2, which reached significance (P<0.001). Accordingly, the Severity of Illness improved from 4.7 to 4.2, and was also significant (P<0.01). Dose reduction is an encouraging strategy to consider for those patients with schizophrenia who have chronically been treated with high-dose antipsychotic polypharmacy, even if judged unavoidable in the past.
机译：简介：抗精神病药通常以高于推荐剂量的剂量使用，有时以联合方案治疗精神分裂症。但是，一般而言，在最近的临床研究中已经放弃了大剂量疗法。在这项研究中，对患有慢性精神分裂症的患者实施了抗精神病药物的减量治疗，其中大多数人（81％）已经接受了抗精神病药的高剂量多药治疗，治疗总量超过1000毫克/天。结果表明，仅减少抗精神病药物的用量即可在41例病例中的23例（56％）中产生良好的结果，而另外13例病例（32％）没有变化。减少剂量仅以五个受试者（12％）失败而告终。总体而言，抗精神病药物的量和数量从每天1984 mg减少到每天812 mg（分别减少59％和从3.6减少到2.2;两者均P <0.0001）。全球功能评估量表从30.6改善到37.2，达到了显着水平（P <0.001）。因此，疾病的严重度从4.7提高到4.2，并且也很显着（P <0.01）。减少剂量是对那些长期接受大剂量抗精神病药物治疗的精神分裂症患者考虑的令人鼓舞的策略，即使过去认为这是不可避免的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号