Relative sensitivity of the Montgomery-Asberg depression rating scale, the Hamilton depression rating scale and the Clinical Global Impressions rating scale in antidepressant clinical trials: a replication analysis.

Khan A; Brodhead AE; Kolts RL

首页> 外文期刊>International clinical psychopharmacology >Relative sensitivity of the Montgomery-Asberg depression rating scale, the Hamilton depression rating scale and the Clinical Global Impressions rating scale in antidepressant clinical trials: a replication analysis.

【24h】

Relative sensitivity of the Montgomery-Asberg depression rating scale, the Hamilton depression rating scale and the Clinical Global Impressions rating scale in antidepressant clinical trials: a replication analysis.

机译：蒙哥马利-阿斯伯格抑郁量表，汉密尔顿抑郁量表和临床总体印象量表在抗抑郁剂临床试验中的相对敏感性：重复分析。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The present study replicates a previous study in which we found that the less frequently used Montgomery-Asberg Depression Rating Scale (MADRS) is as sensitive an instrument in detecting antidepressant-placebo differences in antidepressant clinical trials as the more widely used Hamilton Depression (HAM-D) rating scale. The Clinical Global Impressions Rating Scale for Severity (CGI-S) was also similar to the other two scales. A retrospective chart review was performed on the records of 139 depressed adult patients who participated in six randomized, placebo-controlled, double-blind antidepressant clinical trials at the North-west Clinical Research Centre between 1996 and 2003. The effect size (measured as the mean change in rating with antidepressants minus the mean change for placebo divided by the pooled SD of change) was 0.68 with MADRS, 0.54 with CGI-S and 0.57 with HAM-D. A correlation analysis also revealed a significant positive relationships between baseline MADRS and HAM-D and final MADRS and HAM-D for the total sample, placebo group, and antidepressant group (P<0.01). Further research is needed to examine which scale is the most appropriate to use for each particular antidepressant clinical trial.

机译：本研究重复了先前的研究，其中我们发现，使用频率较低的蒙哥马利-阿斯伯格抑郁量表（MADRS）与使用汉密尔顿抑郁症（HAM- D）等级量表。临床全球严重程度印象评定量表（CGI-S）也与其他两个量表相似。回顾性图表回顾了西北地区临床研究中心在1996年至2003年间参加了6项随机，安慰剂对照，双盲抗抑郁药临床试验的139例抑郁症成年患者的病历。抗抑郁药的平均评分变化减去安慰剂的平均变化除以合并的SD变化）对于MADRS为0.68，对于CGI-S为0.54，对于HAM-D为0.57。相关分析还显示，总样品，安慰剂组和抗抑郁剂组的基线MADRS和HAM-D与最终MADRS和HAM-D之间存在显着的正相关（P <0.01）。需要做进一步的研究来检查哪种量表最适合用于每个特定的抗抑郁药临床试验。

著录项

来源
《International clinical psychopharmacology》 |2004年第3期|共4页
作者
Khan A; Brodhead AE; Kolts RL;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Antidepressive Agents; rating scale; Clinical Trials; Cancer patients and suicide and depression; 抗抑郁药; 临床试验;

机译：Antidepressive Agents;rating scale;Clinical Trials;Cancer patients and suicide and depression;抗抑郁药;临床试验;

相似文献

外文文献
中文文献
专利

1. Relative sensitivity of the Montgomery-Asberg depression rating scale, the Hamilton depression rating scale and the Clinical Global Impressions rating scale in antidepressant clinical trials: a replication analysis. [J] . Khan A, Brodhead AE, Kolts RL International clinical psychopharmacology . 2004,第3期

机译：蒙哥马利-阿斯伯格抑郁量表，汉密尔顿抑郁量表和临床总体印象量表在抗抑郁剂临床试验中的相对敏感性：重复分析。
2. Validation of the 17-item Hamilton Depression Rating Scale definition of response for adults with major depressive disorder using equipercentile linking to Clinical Global Impression scale ratings: analysis of Pharmacogenomic Research Network Antidepressant Medication Pharmacogenomic Study (PGRN-AMPS) data [J] . Bobo William V., Anglero Gabriela C., Jenkins Gregory, Human psychopharmacology: clinical and experimental . 2016,第3期

机译：使用等百分位数链接到临床总体印象量表评分，对重度抑郁症成年人反应的17项汉密尔顿抑郁量表定义进行验证：药物基因组学研究网络抗抑郁药药物基因组学研究（PGRN-AMPS）数据的分析
3. Clinical Validation of the Psychotic Depression Assessment Scale, Hamilton Depression Rating Scale-6, and Brief Psychiatric Rating Scale-5: Results from the Clinical Research Center for Depression Study [J] . Park Seon-Cheol, Jang Eun Young, Kim Jae-Min, Psychiatry Investigation . 2017,第5期

机译：精神病抑郁评估量表，汉密尔顿抑郁量表-6和简短精神病学量表-5的临床验证：抑郁症临床研究中心的结果
4. Measurement Issues of Some Widely Used Instruments May Mask Positive Findings in Medical Research -With Illustration of the Hamilton Rating Scale for Depression (HRSD) in a Large Clinical Trial for Major Depression [C] . Chengwu Yang, Wenle Zhao Second joint biostatistics symposium (2012) . 2012

机译：一些广泛使用的仪器的测量问题可能会掩盖医学研究的积极成果-举例说明在大型抑郁症临床试验中的汉密尔顿抑郁量表（HRSD）
5. Analysis of speech features as potential indicators for depression and high risk suicide and possible predictors for the Hamilton Depression Rating (HAMD) and Beck Depression Inventory scale (BDI-II). [D] . Nik Hashim, Nik Nur Wahidah. 2014

机译：语音特征分析可作为抑郁症和高危自杀的潜在指标，并可以预测汉密尔顿抑郁量表（HAMD）和贝克抑郁量表（BDI-II）。
6. Validation of the 17-item Hamilton Depression Rating Scale definition of response for adults with major depressive disorder using equipercentile linking to Clinical Global Impression scale ratings: analysis of Pharmacogenomic Research Network Antidepressant Medication Pharmacogenomic Study (PGRN-AMPS) data [O] . William V. Bobo, Gabriela C. Angleró, Gregory Jenkins, -1

机译：使用等百分位数链接到临床总体印象量表评分对重度抑郁症成人反应的17项汉密尔顿抑郁量表定义进行验证：药物基因组研究网络抗抑郁药药物基因组学研究（PGRN-AMPS）数据的分析
7. Clinical use of the Hamilton Depression Rating Scale: is increased efficiency possible? A post hoc comparison of Hamilton Depression Rating Scale, Maier and Bech subscales, Clinical Global Impression, and Symptom Checklist-90 scores [O] . Ruhe, H.G., Dekker, J.J., Peen, J., 2005

机译：汉密尔顿抑郁量表的临床使用：是否有可能提高效率？汉密尔顿抑郁量表，Maier和Bech分量表，临床总体印象和症状清单90分的事后比较
8. Reliability and Validity of the Outcome Rating Scale: A Replication Study of a Brief Clinical Measure [R] . Bringhurst, D. L. , Watson, C. W. , Miller, S. D. , 2004

机译：结果评定量表的可靠性和有效性：简要临床测量的复制研究

Relative sensitivity of the Montgomery-Asberg depression rating scale, the Hamilton depression rating scale and the Clinical Global Impressions rating scale in antidepressant clinical trials: a replication analysis.

摘要

著录项

相似文献

相关主题

期刊订阅