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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Interpenetrating polymer network (IPN) hydrogel microspheres for oral controlled release application
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Interpenetrating polymer network (IPN) hydrogel microspheres for oral controlled release application

机译：互穿聚合物网络（IPN）水凝胶微球用于口服控释应用

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摘要

Interpenetrating polymer network (IPN) hydrogel microspheres of sodium carboxymethyl cellulose (NaCMC) and poly(vinyl alcohol) (PVA) were prepared by water-in-oil (w/o) emulsion crosslinking method for oral controlled release delivery of a non-steroidal anti-inflammatory drug, diclofenac sodium (DS). The microspheres were prepared with various ratios of NaCMC to PVA, % drug loading and extent of crosslinking density at a fixed polymer weight. The prepared microspheres with loose and rigid surfaces were evidenced by scanning electron microscope (SEM). Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis confirmed the IPN formation. Differential scanning calorimetry (DSC) study was performed to understand the dispersion nature of drug after encapsulation. The in vitro drug release study was extensively evaluated depending on the process variables in both acid and alkaline media. All the formulations exhibited satisfactory physicochemical and in vitro release characteristics. Release data indicated a non-Fickian trend of drug release from the formulations. Based on the results of this study suggest that DS loaded IPN microspheres were suitable for oral controlled release application.
机译：通过油包水（w / o）乳液交联法制备羧甲基纤维素钠（NaCMC）和聚乙烯醇（PVA）的互穿聚合物网络（IPN）水凝胶微球，用于非甾体的口服控释抗炎药双氯芬酸钠（DS）。以固定的聚合物重量，以各种比例的NaCMC与PVA，药物载量％和交联密度的程度制备微球。制备的具有松散和刚性表面的微球通过扫描电子显微镜（SEM）证明。傅立叶变换红外光谱（FTIR）和X射线衍射（XRD）分析证实了IPN的形成。进行差示扫描量热法（DSC）研究以了解封装后药物的分散性质。根据在酸性和碱性介质中的过程变量，对体外药物释放研究进行了广泛的评估。所有制剂均表现出令人满意的物理化学和体外释放特性。释放数据表明药物从制剂中释放出非费克式趋势。根据这项研究的结果表明，负载DS的IPN微球适用于口服控释应用。

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